Cattle PLGF(Placenta Growth Factor) ELISA Kit
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Human Placenta Growth Factor (PLGF) ELISA Kit |
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DLR-PLGF-Hu-96T | DL Develop | 96T | 511.2 EUR |
Description: A sandwich quantitative ELISA assay kit for detection of Human Placenta Growth Factor (PLGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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DLR-PLGF-Mu-48T | DL Develop | 48T | 380.4 EUR |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Placenta Growth Factor (PLGF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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DLR-PLGF-Mu-96T | DL Develop | 96T | 477.6 EUR |
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Placenta Growth Factor (PLGF) in samples from serum, plasma, tissue homogenates or other biological fluids. |
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Rat Placenta Growth Factor (PLGF) ELISA Kit |
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DLR-PLGF-Ra-48T | DL Develop | 48T | 544.8 EUR |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Placenta Growth Factor (PLGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Rat Placenta Growth Factor (PLGF) ELISA Kit |
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DLR-PLGF-Ra-96T | DL Develop | 96T | 704.4 EUR |
Description: A sandwich quantitative ELISA assay kit for detection of Rat Placenta Growth Factor (PLGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Bovine Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-b-48Tests | Reddot Biotech | 48 Tests | 592.8 EUR |
Bovine Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-b-96Tests | Reddot Biotech | 96 Tests | 820.8 EUR |
Human Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-Hu-48Tests | Reddot Biotech | 48 Tests | 381.6 EUR |
Human Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-Hu-96Tests | Reddot Biotech | 96 Tests | 518.4 EUR |
Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-Mu-48Tests | Reddot Biotech | 48 Tests | 354 EUR |
Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-Mu-96Tests | Reddot Biotech | 96 Tests | 480 EUR |
Rat Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-Ra-48Tests | Reddot Biotech | 48 Tests | 540 EUR |
Rat Placenta Growth Factor (PLGF) ELISA Kit |
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RD-PLGF-Ra-96Tests | Reddot Biotech | 96 Tests | 746.4 EUR |
Bovine Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-b-48Tests | Reddot Biotech | 48 Tests | 619.2 EUR |
Bovine Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-b-96Tests | Reddot Biotech | 96 Tests | 859.2 EUR |
Human Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-Hu-48Tests | Reddot Biotech | 48 Tests | 397.2 EUR |
Human Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-Hu-96Tests | Reddot Biotech | 96 Tests | 541.2 EUR |
Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-Mu-48Tests | Reddot Biotech | 48 Tests | 368.4 EUR |
Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-Mu-96Tests | Reddot Biotech | 96 Tests | 501.6 EUR |
Rat Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-Ra-48Tests | Reddot Biotech | 48 Tests | 564 EUR |
Rat Placenta Growth Factor (PLGF) ELISA Kit |
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RDR-PLGF-Ra-96Tests | Reddot Biotech | 96 Tests | 781.2 EUR |
ELISA kit for Cattle PLGF (Placenta Growth Factor) |
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ELK7526 | ELK Biotech | 1 plate of 96 wells | 631.2 EUR |
Description: A sandwich ELISA kit for detection of Placenta Growth Factor from Cattle in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Placenta Growth Factor (PLGF) Antibody |
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20-abx142140 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody |
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20-abx102283 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody |
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20-abx102284 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody |
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20-abx102285 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody |
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abx433146-200ul | Abbexa | 200 ul | 460.8 EUR |
Placenta Growth Factor (PLGF) Antibody |
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20-abx174070 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody |
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20-abx174071 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody |
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20-abx178023 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody |
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20-abx178024 | Abbexa |
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Recombinant Placenta Growth Factor (PLGF) |
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4-RPA114Hu01 | Cloud-Clone |
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Description: Recombinant Human Placenta Growth Factor expressed in: E.coli |
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Recombinant Placenta Growth Factor (PLGF) |
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4-RPA114Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Placenta Growth Factor expressed in: E.coli |
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Recombinant Placenta Growth Factor (PLGF) |
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4-RPA114Ra01 | Cloud-Clone |
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Description: Recombinant Rat Placenta Growth Factor expressed in: E.coli |
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Human placenta growth factor,PLGF ELISA kit |
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201-12-0139 | SunredBio | 96 tests | 528 EUR |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Rat placenta growth factor,PLGF ELISA kit |
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CN-01525R1 | ChemNorm | 96T | 529.2 EUR |
Rat placenta growth factor,PLGF ELISA kit |
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CN-01525R2 | ChemNorm | 48T | 349.2 EUR |
Rat placenta growth factor, PLGF ELISA kit |
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CSB-E07400r-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Description: Quantitativesandwich ELISA kit for measuring Rat placenta growth factor, PLGF in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Rat placenta growth factor, PLGF ELISA kit |
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1-CSB-E07400r | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Rat placenta growth factor, PLGF in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Mouse placenta growth factor, PLGF ELISA kit |
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CSB-E07401m-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Description: Quantitativecompetitive ELISA kit for measuring Mouse placenta growth factor, PLGF in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Mouse placenta growth factor, PLGF ELISA kit |
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1-CSB-E07401m | Cusabio |
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Description: Quantitativecompetitive ELISA kit for measuring Mouse placenta growth factor, PLGF in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human placenta growth factor, PLGF ELISA kit |
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CSB-E04707h-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Description: Quantitativesandwich ELISA kit for measuring Human placenta growth factor, PLGF in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human placenta growth factor, PLGF ELISA kit |
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1-CSB-E04707h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human placenta growth factor, PLGF in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human placenta growth factor,PLGF ELISA kit |
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CN-03254H1 | ChemNorm | 96T | 530.4 EUR |
Human placenta growth factor,PLGF ELISA kit |
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CN-03254H2 | ChemNorm | 48T | 351.6 EUR |
Mouse placenta growth factor,PLGF ELISA kit |
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CN-02373M1 | ChemNorm | 96T | 565.2 EUR |
Mouse placenta growth factor,PLGF ELISA kit |
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CN-02373M2 | ChemNorm | 48T | 386.4 EUR |
Rat placenta growth factor(PLGF)ELISA Kit |
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GA-E0587RT-48T | GenAsia Biotech | 48T | 380.4 EUR |
Rat placenta growth factor(PLGF)ELISA Kit |
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GA-E0587RT-96T | GenAsia Biotech | 96T | 595.2 EUR |
Rabbit placenta growth factor,PLGF ELISA kit |
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GA-E0011RB-48T | GenAsia Biotech | 48T | 391.2 EUR |
Rabbit placenta growth factor,PLGF ELISA kit |
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GA-E0011RB-96T | GenAsia Biotech | 96T | 628.8 EUR |
Bovine Placenta Growth Factor (PLGF)ELISA Kit |
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GA-E0076BV-48T | GenAsia Biotech | 48T | 403.2 EUR |
Bovine Placenta Growth Factor (PLGF)ELISA Kit |
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GA-E0076BV-96T | GenAsia Biotech | 96T | 640.8 EUR |
Human placenta growth factor(PLGF)ELISA Kit |
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GA-E0077HM-48T | GenAsia Biotech | 48T | 346.8 EUR |
Human placenta growth factor(PLGF)ELISA Kit |
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GA-E0077HM-96T | GenAsia Biotech | 96T | 559.2 EUR |
Mouse placenta growth factor(PLGF)ELISA Kit |
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GA-E0088MS-48T | GenAsia Biotech | 48T | 403.2 EUR |
Mouse placenta growth factor(PLGF)ELISA Kit |
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GA-E0088MS-96T | GenAsia Biotech | 96T | 640.8 EUR |
Mouse Placenta growth factor, PlGF ELISA Kit |
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ELA-E0114m | Lifescience Market | 96 Tests | 1038 EUR |
Rat Placenta growth factor,PlGF ELISA Kit |
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ELA-E0114r | Lifescience Market | 96 Tests | 1063.2 EUR |
Human Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 4091.29 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 442.1 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 580.15 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 2250.68 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Human Placenta Growth Factor (PLGF) ELISA Kit |
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4-SEA114Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Placenta Growth Factor (PLGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 4091.29 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates and other biological fluids. |
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Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 442.1 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates and other biological fluids. |
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Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 580.15 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates and other biological fluids. |
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Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 2250.68 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates and other biological fluids. |
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Mouse Placenta Growth Factor (PLGF) ELISA Kit |
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4-SEA114Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Placenta Growth Factor (PLGF) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Rat Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Ra-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5552.14 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Rat Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Ra-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 562.42 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Rat Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Ra-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 752.02 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Rat Placenta Growth Factor (PLGF) ELISA Kit |
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SEA114Ra-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3024.07 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Placenta Growth Factor (PLGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
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Rat Placenta Growth Factor (PLGF) ELISA Kit |
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4-SEA114Ra | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Placenta Growth Factor (PLGF) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Human placenta growth factor(PLGF)ELISA Kit |
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QY-E01324 | Qayee Biotechnology | 96T | 433.2 EUR |
Rat placenta growth factor(PLGF)ELISA Kit |
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QY-E11065 | Qayee Biotechnology | 96T | 433.2 EUR |
Mouse placenta growth factor(PLGF)ELISA Kit |
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QY-E21188 | Qayee Biotechnology | 96T | 433.2 EUR |
Human Placenta Growth Factor ELISA Kit (PLGF) |
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RK02101 | Abclonal | 96 Tests | 625.2 EUR |
Rat Placenta Growth Factor ELISA Kit (PLGF) |
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RK03896 | Abclonal | 96 Tests | 625.2 EUR |
Rat placenta growth factor,PLGF ELISA kit |
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YLA0306RA-48T | Shanghai YL Biotech | 48T | 465 EUR |
Rat placenta growth factor,PLGF ELISA kit |
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YLA0306RA-96T | Shanghai YL Biotech | 96T | 600 EUR |
Human placenta growth factor,PLGF ELISA kit |
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YLA0410HU-48T | Shanghai YL Biotech | 48T | 435 EUR |
Human placenta growth factor,PLGF ELISA kit |
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YLA0410HU-96T | Shanghai YL Biotech | 96T | 562.5 EUR |
Mouse placenta growth factor,PLGF ELISA kit |
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YLA0480MO-48T | Shanghai YL Biotech | 48T | 465 EUR |
Mouse placenta growth factor,PLGF ELISA kit |
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YLA0480MO-96T | Shanghai YL Biotech | 96T | 600 EUR |
ELISA kit for Rat PLGF (Placenta Growth Factor) |
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ELK2527 | ELK Biotech | 1 plate of 96 wells | 518.4 EUR |
Description: A sandwich ELISA kit for detection of Placenta Growth Factor from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Human PLGF (Placenta Growth Factor) |
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ELK1178 | ELK Biotech | 1 plate of 96 wells | 446.4 EUR |
Description: A sandwich ELISA kit for detection of Placenta Growth Factor from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Mouse PLGF (Placenta Growth Factor) |
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ELK1242 | ELK Biotech | 1 plate of 96 wells | 446.4 EUR |
Description: A sandwich ELISA kit for detection of Placenta Growth Factor from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Mouse Placenta growth factor (PLGF) |
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KTE70764-48T | Abbkine | 48T | 457.2 EUR |
Description: Quantitative sandwich ELISA for measuring Mouse Placenta growth factor (PLGF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Mouse Placenta growth factor (PLGF) |
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KTE70764-5platesof96wells | Abbkine | 5 plates of 96 wells | 3194.4 EUR |
Description: Quantitative sandwich ELISA for measuring Mouse Placenta growth factor (PLGF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Mouse Placenta growth factor (PLGF) |
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KTE70764-96T | Abbkine | 96T | 802.8 EUR |
Description: Quantitative sandwich ELISA for measuring Mouse Placenta growth factor (PLGF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Placenta growth factor (PLGF) |
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KTE100478-48T | Abbkine | 48T | 457.2 EUR |
Description: Quantitative sandwich ELISA for measuring Rat Placenta growth factor (PLGF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Placenta growth factor (PLGF) |
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KTE100478-5platesof96wells | Abbkine | 5 plates of 96 wells | 3194.4 EUR |
Description: Quantitative sandwich ELISA for measuring Rat Placenta growth factor (PLGF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Rat Placenta growth factor (PLGF) |
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KTE100478-96T | Abbkine | 96T | 802.8 EUR |
Description: Quantitative sandwich ELISA for measuring Rat Placenta growth factor (PLGF) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Mouse Placenta Growth Factor (PLGF) Protein |
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20-abx068553 | Abbexa |
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Rat Placenta Growth Factor (PLGF) Protein |
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20-abx068554 | Abbexa |
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Human Placenta Growth Factor (PLGF) Protein |
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20-abx068556 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody (FITC) |
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20-abx271259 | Abbexa |
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Placenta Growth Factor (PLGF) Antibody (Biotin) |
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20-abx271525 | Abbexa |
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Cow Placenta Growth Factor (PLGF) Protein |
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20-abx654740 | Abbexa |
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Plgf Antibody / Pgf / Placenta growth factor |
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R32889 | NSJ Bioreagents | 100 ug | 419 EUR |
PLGF Antibody / PGF / Placenta Growth Factor |
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RQ4653 | NSJ Bioreagents | 100ug | 419 EUR |
PLGF Antibody / PGF / Placenta Growth Factor |
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V3161-100UG | NSJ Bioreagents | 100 ug | 499 EUR |
Description: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR. |
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PLGF Antibody / PGF / Placenta Growth Factor |
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V3161-20UG | NSJ Bioreagents | 20 ug | 219 EUR |
Description: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR. |