Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia.

Many commercial and household products such as lubricants, cosmetics, plastics, and paint contain phthalates, in particular bis-(2-ethyhexyl)-phthalate (DEHP). As a consequence, phthalates have been found in a number of locations and foods (streambeds, household dust, bottled water and dairy products).

Epidemiological and animal studies analysing phthalate exposure in males provide evidence of degradation in sperm quality, associated to an increase in the incidence of genital birth defects and testicular cancers. In the testis, spermatogenesis is maintained throughout life by a small number of spermatogonial stem cells (SSCs) that self-renew or differentiate to produce adequate numbers of spermatozoa.

Disruption or alteration of SSC self-renewal induce decreased sperm count and sperm quality, or may potentially lead to testicular cancer. GDNF, or glial cell-line-derived neurotrophic factor, is a growth factor that is essential for the self-renewal of SSCs and continuous spermatogenesis. In the present study, the SSC-derived cell line C18-4 was used as a model for preliminary assessment of the effects of mono-(2-ethylhexyl)-phthalate (MEHP, main metabolite of DEHP) on spermatogonial stem cells.

ANK3 Antibody

37413 SAB 100ul 319 EUR

ANK3 Antibody

37413-100ul SAB 100ul 302.4 EUR

ANK3 Antibody

1-CSB-PA981926 Cusabio
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  • 100ul
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Description: A polyclonal antibody against ANK3. Recognizes ANK3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100

ANK3 Antibody

E037413 EnoGene 100μg/100μl 255 EUR
Description: Available in various conjugation types.

ANK3 Antibody

DF15475 Affbiotech 100ul 420 EUR

ANK3 Antibody

DF15475-100ul Affinity Biosciences 100ul 280 EUR

ANK3 Antibody

DF15475-200ul Affinity Biosciences 200ul 350 EUR

ANK3 Antibody

CAC11390-100ug Biomatik Corporation 100ug 314 EUR

ANK3 Antibody

CAC11390-50ug Biomatik Corporation 50ug 199.2 EUR

ANK3 Antibody

1-CSB-PA619642LA01HU Cusabio
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  • 100ug
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Description: A polyclonal antibody against ANK3. Recognizes ANK3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

ANK3 Antibody

MBS7108251-005mg MyBiosource 0.05mg 190 EUR

ANK3 Antibody

MBS7108251-01mg MyBiosource 0.1mg 270 EUR

ANK3 Antibody

MBS7108251-5x01mg MyBiosource 5x0.1mg 1205 EUR

ANK3 Antibody

MBS7128560-005mL MyBiosource 0.05mL 190 EUR

ANK3 Antibody

MBS7128560-01mL MyBiosource 0.1mL 270 EUR

ANK3 Antibody

MBS7128560-5x01mL MyBiosource 5x0.1mL 1205 EUR

ANK3 Antibody

MBS9410002-01mL MyBiosource 0.1mL 305 EUR

ANK3 Antibody

MBS9410002-5x01mL MyBiosource 5x0.1mL 1230 EUR

ANK3 Antibody

MBS9630763-01mL MyBiosource 0.1mL 260 EUR

ANK3 Antibody

MBS9630763-02mL MyBiosource 0.2mL 305 EUR

ANK3 Antibody

MBS9630763-5x02mL MyBiosource 5x0.2mL 1220 EUR

ANK3 Antibody

MBS9633146-1mg MyBiosource 1mg 375 EUR

ANK3 Antibody

MBS9633146-5x1mg MyBiosource 5x1mg 1545 EUR

ANK3 Rabbit pAb

MBS9145218-005mL MyBiosource 0.05mL 235 EUR

ANK3 Rabbit pAb

MBS9145218-5x005mL MyBiosource 5x0.05mL 885 EUR

ANK3 Rabbit pAb

A20299 Abclonal 100μL 70.85 EUR

ANK3 siRNA (Mouse)

MBS8209313-15nmol MyBiosource 15nmol 405 EUR

ANK3 siRNA (Mouse)

MBS8209313-30nmol MyBiosource 30nmol 565 EUR

ANK3 siRNA (Mouse)

MBS8209313-5x30nmol MyBiosource 5x30nmol 2450 EUR

ANK3 siRNA (Human)

MBS827671-15nmol MyBiosource 15nmol 405 EUR

ANK3 siRNA (Human)

MBS827671-30nmol MyBiosource 30nmol 565 EUR

ANK3 siRNA (Human)

MBS827671-5x30nmol MyBiosource 5x30nmol 2450 EUR

ANK3 Polyclonal Antibody

A69875 EpiGentek
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  • 100 ?g
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ANK3 Conjugated Antibody

C37413 SAB 100ul 476.4 EUR

ANK3 Polyclonal Antibody

E-AB-92218-120uL Elabscience Biotech 120uL 320 EUR
Description: Unconjugated

ANK3 Polyclonal Antibody

E-AB-92218-200uL Elabscience Biotech 200uL 530 EUR
Description: Unconjugated

ANK3 Polyclonal Antibody

E-AB-92218-60uL Elabscience Biotech 60uL 200 EUR
Description: Unconjugated

ANK3 Polyclonal Antibody

E-AB-92218-each Elabscience Biotech each Ask for price
Description: Unconjugated

ANK3 Polyclonal Antibody

E-AB-13058-120uL Elabscience Biotech 120uL 240 EUR
Description: Unconjugated

ANK3 Polyclonal Antibody

E-AB-13058-200uL Elabscience Biotech 200uL 399 EUR
Description: Unconjugated

ANK3 Polyclonal Antibody

E-AB-13058-20uL Elabscience Biotech 20uL 73 EUR
Description: Unconjugated

ANK3 Polyclonal Antibody

E-AB-13058-60uL Elabscience Biotech 60uL 143 EUR
Description: Unconjugated

ANK3 Polyclonal Antibody

MBS2520445-002mL MyBiosource 0.02mL 135 EUR

ANK3 Polyclonal Antibody

MBS2520445-006mL MyBiosource 0.06mL 190 EUR

ANK3 Polyclonal Antibody

MBS2520445-012mL MyBiosource 0.12mL 265 EUR

ANK3 Polyclonal Antibody

MBS2520445-02mL MyBiosource 0.2mL 415 EUR

ANK3 Polyclonal Antibody

MBS2520445-5x02mL MyBiosource 5x0.2mL 1835 EUR

ANK3 Conjugated Antibody

MBS9447854-01mLAF350 MyBiosource 0.1mL(AF350) 480 EUR

ANK3 Conjugated Antibody

MBS9447854-01mLAF405 MyBiosource 0.1mL(AF405) 480 EUR

ANK3 Conjugated Antibody

MBS9447854-01mLAF488 MyBiosource 0.1mL(AF488) 480 EUR

ANK3 Conjugated Antibody

MBS9447854-01mLAF555 MyBiosource 0.1mL(AF555) 480 EUR

ANK3 Conjugated Antibody

MBS9447854-01mLBiotin MyBiosource 0.1mL(Biotin) 480 EUR

ANK3 Polyclonal Antibody

RD76705A-120uL Reddot Biotech 120μL 360 EUR
Description: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.

ANK3 Polyclonal Antibody

RD76705A-200uL Reddot Biotech 200μL 630 EUR
Description: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.

ANK3 Polyclonal Antibody

RD76705A-20uL Reddot Biotech 20μL 109.5 EUR
Description: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.

ANK3 Polyclonal Antibody

RD76705A-60uL Reddot Biotech 60μL 214.5 EUR
Description: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.

Ankyrin 3 (ANK3) Antibody

20-abx210627 Abbexa
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Ankyrin 3 (ANK3) Antibody

20-abx334144 Abbexa
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  • 100 ug
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Ankyrin G (ANK3) Antibody

abx445015-100ug Abbexa 100 ug 627.6 EUR

Ankyrin 3 (ANK3) Antibody

abx210627-100l Abbexa 100 µl 350 EUR

Ankyrin 3 (ANK3) Antibody

abx210627-50l Abbexa 50 µl 250 EUR

Ankyrin 3 (ANK3) Antibody

abx334144-100g Abbexa 100 µg 362.5 EUR

Ankyrin 3 (ANK3) Antibody

abx334144-20g Abbexa 20 µg 162.5 EUR

Ankyrin 3 (ANK3) Antibody

abx334144-50g Abbexa 50 µg 250 EUR

Ankyrin G (ANK3) Antibody

abx445015-100l Abbexa 100 µl 550 EUR

Ankyrin-3 (ANK3) Antibody

abx433642-100g Abbexa 100 µg 387.5 EUR

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 9, (10ug)

MC221988 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 7, (10ug)

MC222456 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 6, (10ug)

MC223502 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 1, (10ug)

MC224872 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 3, (10ug)

MC224915 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 8, (10ug)

MC225043 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 5, (10ug)

MC225056 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 4, (10ug)

MC225072 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 2, (10ug)

MC225078 Origene Technologies GmbH 10 µg Ask for price

Mouse ANK3 shRNA Plasmid

20-abx969141 Abbexa
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  • 150 µg
  • 300 µg

Human ANK3 shRNA Plasmid

20-abx950201 Abbexa
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  • 150 µg
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ANK3 Antibody, HRP conjugated

1-CSB-PA619642LB01HU Cusabio
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  • 100ug
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Description: A polyclonal antibody against ANK3. Recognizes ANK3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

ANK3 Antibody, HRP conjugated

MBS7108252-005mg MyBiosource 0.05mg 190 EUR

ANK3 Antibody, HRP conjugated

MBS7108252-01mg MyBiosource 0.1mg 270 EUR

ANK3 Antibody, HRP conjugated

MBS7108252-5x01mg MyBiosource 5x0.1mg 1205 EUR

ANK3 Antibody, FITC conjugated

1-CSB-PA619642LC01HU Cusabio
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  • 100ug
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Description: A polyclonal antibody against ANK3. Recognizes ANK3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

ANK3 Antibody, FITC conjugated

MBS7108253-005mg MyBiosource 0.05mg 190 EUR

ANK3 Antibody, FITC conjugated

MBS7108253-01mg MyBiosource 0.1mg 270 EUR

ANK3 Antibody, FITC conjugated

MBS7108253-5x01mg MyBiosource 5x0.1mg 1205 EUR

ANK3 Antibody, Biotin conjugated

1-CSB-PA619642LD01HU Cusabio
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  • 100ug
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Description: A polyclonal antibody against ANK3. Recognizes ANK3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

ANK3 Rabbit Polyclonal Antibody

E10G04684 EnoGene 100 μl 275 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

ANK3 Antibody, Biotin conjugated

MBS7108254-005mg MyBiosource 0.05mg 190 EUR

ANK3 Antibody, Biotin conjugated

MBS7108254-01mg MyBiosource 0.1mg 270 EUR

ANK3 Antibody, Biotin conjugated

MBS7108254-5x01mg MyBiosource 5x0.1mg 1205 EUR

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 9

MR215584 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 1

MR212072 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 2

MR215342 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 5

MR215343 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 8

MR215345 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 3

MR215426 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 6

MR215427 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 4

MR215181 Origene Technologies GmbH 10 µg Ask for price

Ank3 (Myc-DDK-tagged) - Mouse ankyrin 3, epithelial (Ank3), transcript variant 7

MR215182 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 4, (10ug)

MG215181 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 7, (10ug)

MG215182 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 2, (10ug)

MG215342 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 5, (10ug)

MG215343 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 8, (10ug)

MG215345 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 3, (10ug)

MG215426 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 6, (10ug)

MG215427 Origene Technologies GmbH 10 µg Ask for price

Ank3 (GFP-tagged) - Mouse ankyrin 3 epithelial (Ank3) transcript variant 9, (10ug)

MG215584 Origene Technologies GmbH 10 µg Ask for price

Ankyrin G (ANK3) Antibody (PE)

abx444377-100g Abbexa 100 µg 600 EUR

Ankyrin 3 (ANK3) Antibody (HRP)

20-abx334695 Abbexa
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  • 100 ug
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Ankyrin G (ANK3) Antibody (ALP)

abx442412-100ug Abbexa 100 ug 693.6 EUR

Ankyrin G (ANK3) Antibody (APC)

abx442693-100ug Abbexa 100 ug 693.6 EUR

Ankyrin G (ANK3) Antibody (HRP)

abx443534-100ug Abbexa 100 ug 678 EUR

Ankyrin G (ANK3) Antibody (RPE)

abx444377-100ug Abbexa 100 ug 693.6 EUR

Ankyrin G (ANK3) Antibody (APC)

abx442693-100l Abbexa 100 µl 612.5 EUR

Ankyrin G (ANK3) Antibody (HRP)

abx443534-100g Abbexa 100 µg 600 EUR

Ankyrin 3 (ANK3) Antibody (HRP)

abx334695-100g Abbexa 100 µg 362.5 EUR

Ankyrin 3 (ANK3) Antibody (HRP)

abx334695-20g Abbexa 20 µg 162.5 EUR

Ankyrin 3 (ANK3) Antibody (HRP)

abx334695-50g Abbexa 50 µg 250 EUR

Ankyrin 3 (ANK3) Antibody (FITC)

20-abx334696 Abbexa
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Ankyrin G (ANK3) Antibody (FITC)

abx443253-100ug Abbexa 100 ug 678 EUR

Ankyrin G (ANK3) Antibody (FITC)

abx443253-100g Abbexa 100 µg 600 EUR

Ankyrin 3 (ANK3) Antibody (FITC)

abx334696-100g Abbexa 100 µg 362.5 EUR

Ankyrin 3 (ANK3) Antibody (FITC)

abx334696-20g Abbexa 20 µg 162.5 EUR

Ankyrin 3 (ANK3) Antibody (FITC)

abx334696-50g Abbexa 50 µg 250 EUR

Ankyrin G (ANK3) Antibody (PerCP)

abx444096-100ug Abbexa 100 ug 693.6 EUR

Ankyrin G (ANK3) Antibody (PerCP)

abx444096-100g Abbexa 100 µg 612.5 EUR

Ankyrin 3 (ANK3) Antibody (Biotin)

20-abx334697 Abbexa
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  • 100 ug
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Ankyrin G (ANK3) Antibody (Biotin)

abx442973-100ug Abbexa 100 ug 693.6 EUR

Ankyrin G (ANK3) Antibody (Biotin)

abx442973-100g Abbexa 100 µg 600 EUR

Ankyrin 3 (ANK3) Antibody (Biotin)

abx334697-100g Abbexa 100 µg 362.5 EUR

Ankyrin 3 (ANK3) Antibody (Biotin)

abx334697-20g Abbexa 20 µg 162.5 EUR

Ankyrin 3 (ANK3) Antibody (Biotin)

abx334697-50g Abbexa 50 µg 250 EUR

Polyclonal ANK3 / ANKYRIN-G Antibody

APR11411G Leading Biology 0.05mg 580.8 EUR
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human ANK3 / ANKYRIN-G . This antibody is tested and proven to work in the following applications:

Ankyrin G (ANK3) Antibody (ATTO488)

abx440445-100g Abbexa 100 µg 612.5 EUR

Ankyrin G (ANK3) Antibody (ATTO594)

abx441007-100g Abbexa 100 µg 612.5 EUR

Ankyrin G (ANK3) Antibody (ATTO390)

abx440164-100g Abbexa 100 µg 612.5 EUR

Ank3 (untagged ORF) - Rat ankyrin 3, epithelial (Ank3), transcript variant 1, (10 ug)

RN200065 Origene Technologies GmbH 10 µg Ask for price

Ank3 (untagged ORF) - Rat ankyrin 3, epithelial (Ank3), transcript variant 2, (10 ug)

RN200066 Origene Technologies GmbH 10 µg Ask for price

Ankyrin G (ANK3) Antibody (Streptavidin)

abx444658-100ug Abbexa 100 ug 693.6 EUR

Ank3 ORF Vector (Rat) (pORF)

ORF063393 ABM 1.0 ug DNA 3414 EUR

Ank3 ORF Vector (Rat) (pORF)

ORF063394 ABM 1.0 ug DNA 2496 EUR

ANK3 ORF Vector (Human) (pORF)

ORF015542 ABM 1.0 ug DNA Ask for price

Ank3 ORF Vector (Mouse) (pORF)

ORF038598 ABM 1.0 ug DNA 1886.4 EUR

Ank3 ORF Vector (Mouse) (pORF)

ORF038599 ABM 1.0 ug DNA 1886.4 EUR

Ank3 ORF Vector (Mouse) (pORF)

ORF038600 ABM 1.0 ug DNA 1886.4 EUR

Ank3 ORF Vector (Mouse) (pORF)

ORF038601 ABM 1.0 ug DNA 1886.4 EUR

Ank3 ORF Vector (Mouse) (pORF)

ORF038602 ABM 1.0 ug DNA 1886.4 EUR

Ank3 ORF Vector (Mouse) (pORF)

ORF038603 ABM 1.0 ug DNA 607.2 EUR

Ank3 ORF Vector (Mouse) (pORF)

ORF038604 ABM 1.0 ug DNA 607.2 EUR

Our data demonstrate that MEHP disrupts one of the known GDNF signalling pathways in these cells. MEHP induced a decrease of C18-4 cell viability in a time- and dose-dependent manner, as well as a disruption of ERK1/2 activation but not of SRC signalling. As a result, we observed a decrease of expression of the transcription factor FOS, which is downstream of the GDNF/ERK1/2 axis in these cells. Taken together, our data suggest that MEHP exposure affects SSC proliferation through inhibition of specific signalling molecules.