Human MLH3(MutL Homolog 3) ELISA Kit
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Human MutL Homolog 3 (MLH3) ELISA Kit |
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EKN50428-48T | Biomatik Corporation | 48T | 380.31 EUR |
Human MutL Homolog 3 (MLH3) ELISA Kit |
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EKN50428-5x96T | Biomatik Corporation | 5x96T | 2580.68 EUR |
Human MutL Homolog 3 (MLH3) ELISA Kit |
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EKN50428-96T | Biomatik Corporation | 96T | 543.3 EUR |
Human MutL Homolog 3 (MLH3) ELISA Kit |
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EKU09317-48T | Biomatik Corporation | 48T | 610.82 EUR |
Human MutL Homolog 3 (MLH3) ELISA Kit |
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EKU09317-5x96T | Biomatik Corporation | 5x96T | 4144.85 EUR |
Human MutL Homolog 3 (MLH3) ELISA Kit |
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EKU09317-96T | Biomatik Corporation | 96T | 872.6 EUR |
ELISA kit for Human MLH3 (MutL Homolog 3) |
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ELK7522 | ELK Biotech | 1 plate of 96 wells | 518.4 EUR |
Description: A sandwich ELISA kit for detection of MutL Homolog 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Human MutL Homolog 3 (MLH3) CLIA Kit |
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20-abx495965 | Abbexa |
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MutL Homolog 3 (MLH3) Antibody |
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abx146077-100ug | Abbexa | 100 ug | 469.2 EUR |
MutL Homolog 3 (MLH3) Antibody |
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20-abx324670 | Abbexa |
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MutL Homolog 3 (MLH3) Antibody |
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abx331047-100ul | Abbexa | 100 ul | 510 EUR |
MutL Homolog 3 (MLH3) Antibody |
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20-abx014047 | Abbexa |
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MutL Homolog 3 (MLH3) Antibody |
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abx432972-200ul | Abbexa | 200 ul | 343.2 EUR |
MutL Homolog 3 (MLH3) Antibody |
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20-abx006534 | Abbexa |
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Human MLH1(MutL Homolog 1) ELISA Kit |
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ELK4307-48T | ELK Biotech | 48T | Ask for price |
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MLH1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MLH1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MLH1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MLH1 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Human MLH1(MutL Homolog 1) ELISA Kit |
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ELK4307-96T | ELK Biotech | 96T | Ask for price |
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MLH1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MLH1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MLH1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MLH1 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Mlh3 (GFP-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3) |
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MG211974 | Origene Technologies GmbH | 10 µg | Ask for price |
Mlh3 (untagged) - Mouse mutL homolog 3 (E coli) (Mlh3), (10ug) |
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MC224412 | Origene Technologies GmbH | 10 µg | Ask for price |
MLH3 (untagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2 |
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SC127828 | Origene Technologies GmbH | 10 µg | Ask for price |
MLH3 (untagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
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SC310948 | Origene Technologies GmbH | 10 µg | Ask for price |
MutL Homolog 3 (MLH3) Magnetic Luminex Assay Kit |
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LKU606805-96T | Biomatik Corporation | 96T | 1062.6 EUR |
Human MutL Homolog 1 ELISA Kit (MLH1) |
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RK01858 | Abclonal | 96 Tests | 625.2 EUR |
MLH3 (GFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2 |
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RG212150 | Origene Technologies GmbH | 10 µg | Ask for price |
MLH3 (GFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
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RG221591 | Origene Technologies GmbH | 10 µg | Ask for price |
Mlh3 (Myc-DDK-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3) |
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MR211974 | Origene Technologies GmbH | 10 µg | Ask for price |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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20-abx152407 | Abbexa |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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DLR-MLH1-Hu-48T | DL Develop | 48T | 620.4 EUR |
Description: A sandwich quantitative ELISA assay kit for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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DLR-MLH1-Hu-96T | DL Develop | 96T | 807.6 EUR |
Description: A sandwich quantitative ELISA assay kit for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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SEJ742Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 572.76 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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SEJ742Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3090.6 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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4-SEJ742Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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EKU06045-48T | Biomatik Corporation | 48T | 555.66 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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EKU06045-5x96T | Biomatik Corporation | 5x96T | 3770.55 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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EKU06045-96T | Biomatik Corporation | 96T | 793.8 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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EKN47156-48T | Biomatik Corporation | 48T | 378.7 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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EKN47156-5x96T | Biomatik Corporation | 5x96T | 2569.75 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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EKN47156-96T | Biomatik Corporation | 96T | 541 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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RD-MLH1-Hu-48Tests | Reddot Biotech | 48 Tests | 625.2 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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RD-MLH1-Hu-96Tests | Reddot Biotech | 96 Tests | 867.6 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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RDR-MLH1-Hu-48Tests | Reddot Biotech | 48 Tests | 652.8 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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RDR-MLH1-Hu-96Tests | Reddot Biotech | 96 Tests | 907.2 EUR |
Human MutL Homolog 1 (MLH1) ELISA Kit |
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DL-MLH1-Hu | DL Develop | 96T | 441 EUR |
Description: tissue homogenates, cell lysates or other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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DLR-MLH1-Hu | DL Develop | 96T | 463 EUR |
Description: tissue homogenates, cell lysates or other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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SEJ742Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5677.8 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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SEJ742Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 766.8 EUR |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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RDR-MLH1-Hu-48T | Reddot Biotech | 48T | 475.34 EUR |
Description: tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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RDR-MLH1-Hu-96T | Reddot Biotech | 96T | 679.04 EUR |
Description: tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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RD-MLH1-Hu-48T | Reddot Biotech | 48T | 452.7 EUR |
Description: tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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RD-MLH1-Hu-96T | Reddot Biotech | 96T | 646.7 EUR |
Description: tissue homogenates, cell lysates and other biological fluids. |
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Human MutL Homolog 1 (MLH1) ELISA Kit |
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EK15463 | SAB | 96Т | 768 EUR |
Mlh3 (untagged ORF) - Rat mutL homolog 3 (E. coli) (Mlh3), (10 ug) |
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RN209710 | Origene Technologies GmbH | 10 µg | Ask for price |
ELISA kit for Human MLH1 (MutL Homolog 1) |
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ELK4307 | ELK Biotech | 1 plate of 96 wells | 518.4 EUR |
Description: A sandwich ELISA kit for detection of MutL Homolog 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2 |
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RC212150 | Origene Technologies GmbH | 10 µg | Ask for price |
MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
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RC221591 | Origene Technologies GmbH | 10 µg | Ask for price |
Mlh3 (Myc-DDK-tagged ORF) - Rat mutL homolog 3 (E. coli) (Mlh3), (10 ug) |
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RR209710 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Mlh3 (mGFP-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3) |
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MR211974L4 | Origene Technologies GmbH | 10 µg | Ask for price |
ELISA Kit for MutL Homolog 1 (MLH1) |
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SEJ742Hu | Cloud-Clone | 96Т | 700 EUR |
Lenti-ORF clone of MLH3 (mGFP-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
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RC221591L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Mlh3 (Myc-DDK-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3) |
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MR211974L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti-ORF clone of MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
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RC221591L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Human MutL Homolog 1 (MLH1) CLIA Kit |
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20-abx495774 | Abbexa |
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Lenti ORF particles, Mlh3 (GFP-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3), 200ul, >10^7 TU/mL |
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MR211974L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, MLH3 (mGFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, 200ul, >10^7 TU/mL |
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RC212150L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, MLH3 (mGFP-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1, 200ul, >10^7 TU/mL |
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RC221591L4V | Origene Technologies GmbH | 200 µl | Ask for price |
MLH1 (MutL Homolog 1) |
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MO47010 | Neuromics | 100 ul | 418.8 EUR |
Human MutL Homolog 1 (MLH1) Protein |
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20-abx654421 | Abbexa |
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Lenti ORF particles, Mlh3 (Myc-DDK-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3), 200ul, >10^7 TU/mL |
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MR211974L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, MLH3 (Myc-DDK tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, 200ul, >10^7 TU/mL |
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RC212150L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1, 200ul, >10^7 TU/mL |
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RC221591L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF clone of Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, mGFP tagged |
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RC212150L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Human MutL Homolog 1 ELISA Kit |
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IHUMLH1KT | Innovative research | each | 733 EUR |
Description: Human MutL Homolog 1 ELISA Kit |
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Lenti ORF clone of Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, Myc-DDK-tagged |
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RC212150L3 | Origene Technologies GmbH | 10 µg | Ask for price |
MutL Homolog 1 (MLH1) Antibody |
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20-abx317973 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx241566 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx241567 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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abx235213-100ug | Abbexa | 100 ug | 577.2 EUR |
MutL Homolog 1 (MLH1) Antibody |
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20-abx173641 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx177638 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx113897 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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abx026385-400ul | Abbexa | 400 ul | 627.6 EUR |
MutL Homolog 1 (MLH1) Antibody |
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abx026385-80l | Abbexa | 80 µl | 343.2 EUR |
MutL Homolog 1 (MLH1) Antibody |
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abx025515-100ul | Abbexa | 100 ul | 627.6 EUR |
MutL Homolog 1 (MLH1) Antibody |
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20-abx014046 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx328114 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx002899 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx008989 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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20-abx000639 | Abbexa |
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MutL Homolog 1 (MLH1) Antibody |
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abx012221-100ul | Abbexa | 100 ul | 493.2 EUR |
MLH1 Antibody / MutL Homolog 1 |
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V8749-100UG | NSJ Bioreagents | 100 ug | 349.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
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MLH1 Antibody / MutL Homolog 1 |
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V8749-20UG | NSJ Bioreagents | 20 ug | 153.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
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MLH1 Antibody / MutL Homolog 1 |
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V8749SAF-100UG | NSJ Bioreagents | 100 ug | 349.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
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MLH1 Antibody / MutL Homolog 1 |
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V9166-100UG | NSJ Bioreagents | 100ug | 349.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
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MLH1 Antibody / MutL Homolog 1 |
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V9166-20UG | NSJ Bioreagents | 20ug | 153.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
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MLH1 Antibody / MutL Homolog 1 |
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V9166SAF-100UG | NSJ Bioreagents | 100ug | 349.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
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MLH1 Antibody / MutL Homolog 1 |
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V9349-100UG | NSJ Bioreagents | 100ug | 349.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |
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MLH1 Antibody / MutL Homolog 1 |
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V9349-20UG | NSJ Bioreagents | 20ug | 153.3 EUR |
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis. |