Human MLH3(MutL Homolog 3) ELISA Kit

Human MLH3(MutL Homolog 3) ELISA Kit

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Human MutL Homolog 3 (MLH3) ELISA Kit

EKN50428-48T Biomatik Corporation 48T 380.31 EUR

Human MutL Homolog 3 (MLH3) ELISA Kit

EKN50428-5x96T Biomatik Corporation 5x96T 2580.68 EUR

Human MutL Homolog 3 (MLH3) ELISA Kit

EKN50428-96T Biomatik Corporation 96T 543.3 EUR

Human MutL Homolog 3 (MLH3) ELISA Kit

EKU09317-48T Biomatik Corporation 48T 610.82 EUR

Human MutL Homolog 3 (MLH3) ELISA Kit

EKU09317-5x96T Biomatik Corporation 5x96T 4144.85 EUR

Human MutL Homolog 3 (MLH3) ELISA Kit

EKU09317-96T Biomatik Corporation 96T 872.6 EUR

ELISA kit for Human MLH3 (MutL Homolog 3)

ELK7522 ELK Biotech 1 plate of 96 wells 518.4 EUR
Description: A sandwich ELISA kit for detection of MutL Homolog 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human MutL Homolog 3 (MLH3) CLIA Kit

20-abx495965 Abbexa
  • 10282.80 EUR
  • 5472.00 EUR
  • 1262.40 EUR
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

MutL Homolog 3 (MLH3) Antibody

abx146077-100ug Abbexa 100 ug 469.2 EUR

MutL Homolog 3 (MLH3) Antibody

20-abx324670 Abbexa
  • 376.80 EUR
  • 292.80 EUR
  • 100 ug
  • 50 ug

MutL Homolog 3 (MLH3) Antibody

abx331047-100ul Abbexa 100 ul 510 EUR

MutL Homolog 3 (MLH3) Antibody

20-abx014047 Abbexa
  • 376.80 EUR
  • 117.60 EUR
  • 477.60 EUR
  • 594.00 EUR
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

MutL Homolog 3 (MLH3) Antibody

abx432972-200ul Abbexa 200 ul 343.2 EUR

MutL Homolog 3 (MLH3) Antibody

20-abx006534 Abbexa
  • 493.20 EUR
  • 710.40 EUR
  • 218.40 EUR
  • 376.80 EUR
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Human MLH1(MutL Homolog 1) ELISA Kit

ELK4307-48T ELK Biotech 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MLH1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MLH1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MLH1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MLH1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human MLH1(MutL Homolog 1) ELISA Kit

ELK4307-96T ELK Biotech 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MLH1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MLH1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MLH1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MLH1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Mlh3 (GFP-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3)

MG211974 Origene Technologies GmbH 10 µg Ask for price

Mlh3 (untagged) - Mouse mutL homolog 3 (E coli) (Mlh3), (10ug)

MC224412 Origene Technologies GmbH 10 µg Ask for price

MLH3 (untagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2

SC127828 Origene Technologies GmbH 10 µg Ask for price

MLH3 (untagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1

SC310948 Origene Technologies GmbH 10 µg Ask for price

MutL Homolog 3 (MLH3) Magnetic Luminex Assay Kit

LKU606805-96T Biomatik Corporation 96T 1062.6 EUR

Human MutL Homolog 1 ELISA Kit (MLH1)

RK01858 Abclonal 96 Tests 625.2 EUR

MLH3 (GFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2

RG212150 Origene Technologies GmbH 10 µg Ask for price

MLH3 (GFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1

RG221591 Origene Technologies GmbH 10 µg Ask for price

Mlh3 (Myc-DDK-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3)

MR211974 Origene Technologies GmbH 10 µg Ask for price

Human MutL Homolog 1 (MLH1) ELISA Kit

20-abx152407 Abbexa
  • 8853.60 EUR
  • 4719.60 EUR
  • 1093.20 EUR
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human MutL Homolog 1 (MLH1) ELISA Kit

DLR-MLH1-Hu-48T DL Develop 48T 620.4 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

DLR-MLH1-Hu-96T DL Develop 96T 807.6 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

SEJ742Hu-1x48wellstestplate Cloud-Clone 1x48-wells test plate 572.76 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

SEJ742Hu-5x96wellstestplate Cloud-Clone 5x96-wells test plate 3090.6 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

4-SEJ742Hu Cloud-Clone
  • 5738.40 EUR
  • 3031.20 EUR
  • 768.00 EUR
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human MutL Homolog 1 (MLH1) ELISA Kit

EKU06045-48T Biomatik Corporation 48T 555.66 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

EKU06045-5x96T Biomatik Corporation 5x96T 3770.55 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

EKU06045-96T Biomatik Corporation 96T 793.8 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

EKN47156-48T Biomatik Corporation 48T 378.7 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

EKN47156-5x96T Biomatik Corporation 5x96T 2569.75 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

EKN47156-96T Biomatik Corporation 96T 541 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

RD-MLH1-Hu-48Tests Reddot Biotech 48 Tests 625.2 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

RD-MLH1-Hu-96Tests Reddot Biotech 96 Tests 867.6 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

RDR-MLH1-Hu-48Tests Reddot Biotech 48 Tests 652.8 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

RDR-MLH1-Hu-96Tests Reddot Biotech 96 Tests 907.2 EUR

Human MutL Homolog 1 (MLH1) ELISA Kit

DL-MLH1-Hu DL Develop 96T 441 EUR
Description: tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

DLR-MLH1-Hu DL Develop 96T 463 EUR
Description: tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

SEJ742Hu-10x96wellstestplate Cloud-Clone 10x96-wells test plate 5677.8 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

SEJ742Hu-1x96wellstestplate Cloud-Clone 1x96-wells test plate 766.8 EUR
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

RDR-MLH1-Hu-48T Reddot Biotech 48T 475.34 EUR
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

RDR-MLH1-Hu-96T Reddot Biotech 96T 679.04 EUR
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

RD-MLH1-Hu-48T Reddot Biotech 48T 452.7 EUR
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

RD-MLH1-Hu-96T Reddot Biotech 96T 646.7 EUR
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit

EK15463 SAB 96Т 768 EUR

Mlh3 (untagged ORF) - Rat mutL homolog 3 (E. coli) (Mlh3), (10 ug)

RN209710 Origene Technologies GmbH 10 µg Ask for price

ELISA kit for Human MLH1 (MutL Homolog 1)

ELK4307 ELK Biotech 1 plate of 96 wells 518.4 EUR
Description: A sandwich ELISA kit for detection of MutL Homolog 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2

RC212150 Origene Technologies GmbH 10 µg Ask for price

MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1

RC221591 Origene Technologies GmbH 10 µg Ask for price

Mlh3 (Myc-DDK-tagged ORF) - Rat mutL homolog 3 (E. coli) (Mlh3), (10 ug)

RR209710 Origene Technologies GmbH 10 µg Ask for price

Lenti ORF clone of Mlh3 (mGFP-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3)

MR211974L4 Origene Technologies GmbH 10 µg Ask for price

ELISA Kit for MutL Homolog 1 (MLH1)

SEJ742Hu Cloud-Clone 96Т 700 EUR

Lenti-ORF clone of MLH3 (mGFP-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1

RC221591L4 Origene Technologies GmbH 10 µg Ask for price

Lenti ORF clone of Mlh3 (Myc-DDK-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3)

MR211974L3 Origene Technologies GmbH 10 µg Ask for price

Lenti-ORF clone of MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1

RC221591L3 Origene Technologies GmbH 10 µg Ask for price

Human MutL Homolog 1 (MLH1) CLIA Kit

20-abx495774 Abbexa
  • 9567.60 EUR
  • 5095.20 EUR
  • 1177.20 EUR
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Lenti ORF particles, Mlh3 (GFP-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3), 200ul, >10^7 TU/mL

MR211974L4V Origene Technologies GmbH 200 µl Ask for price

Lenti ORF particles, MLH3 (mGFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, 200ul, >10^7 TU/mL

RC212150L4V Origene Technologies GmbH 200 µl Ask for price

Lenti ORF particles, MLH3 (mGFP-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1, 200ul, >10^7 TU/mL

RC221591L4V Origene Technologies GmbH 200 µl Ask for price

MLH1 (MutL Homolog 1)

MO47010 Neuromics 100 ul 418.8 EUR

Human MutL Homolog 1 (MLH1) Protein

20-abx654421 Abbexa
  • 693.60 EUR
  • 309.60 EUR
  • 2064.00 EUR
  • 828.00 EUR
  • 510.00 EUR
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Lenti ORF particles, Mlh3 (Myc-DDK-tagged) - Mouse mutL homolog 3 (E coli) (Mlh3), 200ul, >10^7 TU/mL

MR211974L3V Origene Technologies GmbH 200 µl Ask for price

Lenti ORF particles, MLH3 (Myc-DDK tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, 200ul, >10^7 TU/mL

RC212150L3V Origene Technologies GmbH 200 µl Ask for price

Lenti ORF particles, MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1, 200ul, >10^7 TU/mL

RC221591L3V Origene Technologies GmbH 200 µl Ask for price

Lenti ORF clone of Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, mGFP tagged

RC212150L4 Origene Technologies GmbH 10 µg Ask for price

Human MutL Homolog 1 ELISA Kit

IHUMLH1KT Innovative research each 733 EUR
Description: Human MutL Homolog 1 ELISA Kit

Lenti ORF clone of Human mutL homolog 3 (E. coli) (MLH3), transcript variant 2, Myc-DDK-tagged

RC212150L3 Origene Technologies GmbH 10 µg Ask for price

MutL Homolog 1 (MLH1) Antibody

20-abx317973 Abbexa
  • 493.20 EUR
  • 2214.00 EUR
  • 718.80 EUR
  • 218.40 EUR
  • 360.00 EUR
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

MutL Homolog 1 (MLH1) Antibody

20-abx241566 Abbexa
  • 493.20 EUR
  • 360.00 EUR
  • 100 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody

20-abx241567 Abbexa
  • 493.20 EUR
  • 360.00 EUR
  • 100 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody

abx235213-100ug Abbexa 100 ug 577.2 EUR

MutL Homolog 1 (MLH1) Antibody

20-abx173641 Abbexa
  • 1028.40 EUR
  • 526.80 EUR
  • 1 mg
  • 200 ug

MutL Homolog 1 (MLH1) Antibody

20-abx177638 Abbexa
  • 1446.00 EUR
  • 693.60 EUR
  • 1 mg
  • 200 ug

MutL Homolog 1 (MLH1) Antibody

20-abx113897 Abbexa
  • 878.40 EUR
  • 477.60 EUR
  • 150 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody

abx026385-400ul Abbexa 400 ul 627.6 EUR

MutL Homolog 1 (MLH1) Antibody

abx026385-80l Abbexa 80 µl 343.2 EUR

MutL Homolog 1 (MLH1) Antibody

abx025515-100ul Abbexa 100 ul 627.6 EUR

MutL Homolog 1 (MLH1) Antibody

20-abx014046 Abbexa
  • 376.80 EUR
  • 117.60 EUR
  • 477.60 EUR
  • 142.80 EUR
  • 594.00 EUR
  • 100 ug
  • 10 ug
  • 200 ug
  • 20 ug
  • 300 µg

MutL Homolog 1 (MLH1) Antibody

20-abx328114 Abbexa
  • 376.80 EUR
  • 292.80 EUR
  • 100 ug
  • 50 ug

MutL Homolog 1 (MLH1) Antibody

20-abx002899 Abbexa
  • 493.20 EUR
  • 710.40 EUR
  • 100 ul
  • 200 ul

MutL Homolog 1 (MLH1) Antibody

20-abx008989 Abbexa
  • 360.00 EUR
  • 526.80 EUR
  • 226.80 EUR
  • 100 ul
  • 200 ul
  • 30 ul

MutL Homolog 1 (MLH1) Antibody

20-abx000639 Abbexa
  • 493.20 EUR
  • 710.40 EUR
  • 218.40 EUR
  • 376.80 EUR
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody

abx012221-100ul Abbexa 100 ul 493.2 EUR

MLH1 Antibody / MutL Homolog 1

V8749-100UG NSJ Bioreagents 100 ug 349.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1

V8749-20UG NSJ Bioreagents 20 ug 153.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1

V8749SAF-100UG NSJ Bioreagents 100 ug 349.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1

V9166-100UG NSJ Bioreagents 100ug 349.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1

V9166-20UG NSJ Bioreagents 20ug 153.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1

V9166SAF-100UG NSJ Bioreagents 100ug 349.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1

V9349-100UG NSJ Bioreagents 100ug 349.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1

V9349-20UG NSJ Bioreagents 20ug 153.3 EUR
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

Human MLH3(MutL Homolog 3) ELISA Kit