Mono-(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles.

Mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of the most commonly used plasticizer, di-(2-ethylhexyl) phthalate, and is considered to be a reproductive toxicant. However, little is known about the effects of MEHP on ovarian antral follicles.

Thus, the present study tested the hypothesis that MEHP inhibits follicle growth via oxidative stress pathways. The data indicate that MEHP increases reactive oxygen species (ROS) levels and inhibits follicle growth in antral follicles, whereas N-acetylcysteine (NAC; an antioxidant) restores ROS levels to control levels and rescues follicles from MEHP-induced inhibition of follicle growth.

To further analyze the mechanism by which MEHP induces oxidative stress and inhibits follicle growth, the expression and activities of various key antioxidant enzymes (copper/zinc superoxide dismutase [SOD1], glutathione peroxidase [GPX], and catalase [CAT]) and the expression of key cell-cycle regulators (Ccnd2, Ccne1, and Cdk4) and apoptotic regulators (Bcl-2 and Bax) were compared in control and MEHP-treated follicles.

The data indicate that MEHP inhibits the expression and activities of SOD1 and GPX; does not inhibit Cat expression; inhibits the expression of Ccnd2, Ccne1, Cdk4, and Bcl-2; but increases the expression of Bax compared to controls. Furthermore, NAC blocks these toxic effects of MEHP.

Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-10ug
QP8982-ye-10ug	EnQuireBio	10ug	369.6 EUR
Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-50ug
QP8982-ye-50ug	EnQuireBio	50ug	500.4 EUR
Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-100ug
QP8982-ye-100ug	EnQuireBio	100ug	804 EUR
Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-200ug
QP8982-ye-200ug	EnQuireBio	200ug	1282.8 EUR
Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-500ug
QP8982-ye-500ug	EnQuireBio	500ug	2164.8 EUR
Annexin VII (Annexin VII) Antibody
abx230439-100ug	Abbexa	100 ug	610.8 EUR
Horse ANX5(Annexin 5) ELISA Kit
EHS0047	FN Test	96T	681.12 EUR
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Horse;Sensitivity: 0.938 ng/ml
Annexin VIII (Annexin VIII) Antibody
abx230440-100ug	Abbexa	100 ug	577.2 EUR
Annexin VI/Annexin A6 Rabbit pAb
E2382616	EnoGene	100ul	225 EUR
Description: Available in various conjugation types.
Annexin A4/Annexin IV Rabbit mAb
A9203	Abclonal	50μL	1557.4 EUR
Description: A synthetic peptide of human CD62P/P-selectin.
Annexin A5/Annexin V Rabbit mAb
A9262	Abclonal	200μL	213.2 EUR
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 165-225 of human CD79a (NP_001774.1).
Annexin A6/Annexin VI Rabbit mAb
A22038	Abclonal	500μL	83.2 EUR
Description: Recombinant protein of Human PMF1.
Annexin V 647
E16FXP023a-100T	EnoGene	100 tests	433.33 EUR
Description: Available in various conjugation types.
Annexin A1
PR27207	Neuromics	2 ug	465.6 EUR
Annexin A2
PR27211	Neuromics	5 ug	229.2 EUR
Annexin A3
PR27212	Neuromics	5 ug	229.2 EUR
Annexin A4
PR27213	Neuromics	2 ug	229.2 EUR
Annexin A5
PR27214	Neuromics	5 ug	229.2 EUR
Annexin A6
PR27215	Neuromics	2 ug	229.2 EUR
Annexin A7
PR27216	Neuromics	5 ug	229.2 EUR
Annexin A8
PR27217	Neuromics	5 ug	229.2 EUR
Annexin A3
E8ER1802-50	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin A1
E8ER1803-70	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin A7
E8ER1903-73	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin V
E8ET1702-62	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin A2
E8ET1704-49	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin IV
E8ET7108-56	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin A10
PR27208	Neuromics	5 ug	229.2 EUR
Annexin A11
PR27209	Neuromics	5 ug	229.2 EUR
Annexin A13
PR27210	Neuromics	2 ug	229.2 EUR
Annexin A13
E8ER1903-72	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin A10
E8ET1610-57	EnoGene	100ul	275 EUR
Description: Available in various conjugation types.
Annexin Peptide
45-007P	ProSci	0.1 mg	405.6 EUR
Description: (NT) Annexin A11 Peptide
Annexin Peptide
45-008P	ProSci	0.1 mg	405.6 EUR
Description: (NT) Annexin A2 Peptide
Recombinant human Annexin A5/Annexin V/ANXA5 Protein
RP01180	Abclonal	10 μg	186 EUR
Annexin V (PE)
abx090613-100tests	Abbexa	100 tests	644.4 EUR
Annexin V PE
EXB0027	ExBio	100 tests	244.8 EUR
Annexin V (APC)
abx090615-100tests	Abbexa	100 tests	718.8 EUR
Annexin V APC
EXB0028	ExBio	100 tests	244.8 EUR
Annexin-2 Antibody
39396-100ul	SAB	100ul	468 EUR
Annexin-2 Antibody
E312231	EnoGene	200ul	275 EUR
Description: Available in various conjugation types.
Annexin-2 Antibody
E300092	EnoGene	100ug/200ul	275 EUR
Description: Available in various conjugation types.
Polyclonal ANXA6/Annexin A6/Annexin VI Antibody (aa1-50)
APR02865G	Leading Biology	0.05ml	580.8 EUR
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ANXA6/Annexin A6/Annexin VI (aa1-50). This antibody is tested and proven to work in the following applications:
Annexin V (FITC)
abx090611-100tests	Abbexa	100 tests	510 EUR
Annexin V FITC
EXB0024	ExBio	100 tests	244.8 EUR
Annexin V- FITC
E16FXP018a-100T	EnoGene	100 tests	400 EUR
Description: Available in various conjugation types.
Annexin V, CF770
29046	Biotium	25ug	410.4 EUR
Description: Minimum order quantity: 1 unit of 25ug
Annexin V, CF790
29047	Biotium	25ug	439.2 EUR
Description: Minimum order quantity: 1 unit of 25ug
Annexin A3 siRNA
20-abx907669	Abbexa	661.20 EUR 878.40 EUR	15 nmol 30 nmol
Annexin A3 siRNA
20-abx907670	Abbexa	661.20 EUR 878.40 EUR	15 nmol 30 nmol
Annexin V siRNA
20-abx907673	Abbexa	661.20 EUR 878.40 EUR	15 nmol 30 nmol
Annexin V siRNA
20-abx907674	Abbexa	661.20 EUR 878.40 EUR	15 nmol 30 nmol
Annexin A3 siRNA
20-abx900342	Abbexa	661.20 EUR 878.40 EUR	15 nmol 30 nmol
Annexin V siRNA
20-abx900343	Abbexa	661.20 EUR 878.40 EUR	15 nmol 30 nmol
ANXA1 (Annexin A1)
MO47023	Neuromics	100 ul	418.8 EUR
Annexin A2/ANXA2
E21-205	EnoGene	10ug	411.6 EUR
Annexin V， Human
E34M143H	EnoGene	5 μg	155 EUR
Annexin V, sulforhodamine 101 conjugate (Texas-Red Annexin V)
29002	Biotium	0.5ML	332.4 EUR
Description: Minimum order quantity: 1 unit of 0.5ML
Annexin A5 Protein
20-abx260555	Abbexa	3433.20 EUR 393.60 EUR 276.00 EUR	1 mg 20 ug 5 ug
Annexin A3 Protein
20-abx260563	Abbexa	3433.20 EUR 393.60 EUR 276.00 EUR	1 mg 20 ug 5 ug
Annexin A7 Protein
20-abx261405	Abbexa	4101.60 EUR 393.60 EUR 276.00 EUR	1 mg 20 ug 5 ug
Annexin A8 Protein
20-abx261421	Abbexa	4101.60 EUR 393.60 EUR 276.00 EUR	1 mg 20 ug 5 ug
Annexin A4 Protein
20-abx262872	Abbexa	393.60 EUR 7676.40 EUR 276.00 EUR	10 ug 1 mg 2 µg
Annexin A6 Protein
20-abx262873	Abbexa	393.60 EUR 7676.40 EUR 276.00 EUR	10 ug 1 mg 2 µg
Annexin A1 protein
30R-1291	Fitzgerald	20 ug	548.4 EUR
Description: Purified recombinant Human Annexin A1 protein
Annexin A5 protein
30R-1406	Fitzgerald	100 ug	321.6 EUR
Description: Purified recombinant Human Annexin A5 protein
Annexin A3 protein
30R-1453	Fitzgerald	100 ug	321.6 EUR
Description: Purified recombinant Human Annexin A3 protein
Annexin A4 protein
30R-1463	Fitzgerald	100 ug	703.2 EUR
Description: Purified recombinant Human Annexin A4 protein
Annexin A5 protein
30R-3209	Fitzgerald	50 ug	308.4 EUR
Description: Purified recombinant Annexin A5 protein
Annexin A3 Protein
abx061599-200ug	Abbexa	200 ug	1528.8 EUR
Annexin A1 Peptide
46-785P	ProSci	0.1 mg	405.6 EUR
Description: ANXA1 Peptide
Recombinant human Annexin A5/Annexin V/ANXA5 Protein, His Tag
E40KMP1303	EnoGene	20ug	495 EUR
Annexin A13 Protein
20-abx261320	Abbexa	4101.60 EUR 393.60 EUR 276.00 EUR	1 mg 20 ug 5 ug
Annexin I antibody
10-2468	Fitzgerald	250 ug	590.4 EUR
Description: Mouse monoclonal Annexin I antibody
Annexin I antibody
10-2469	Fitzgerald	250 ug	590.4 EUR
Description: Mouse monoclonal Annexin I antibody
Annexin 1 antibody
10R-11422	Fitzgerald	100 ul	418.8 EUR
Description: Mouse Monoclonal Annexin 1 antibody
Annexin V antibody
10R-7939	Fitzgerald	100 ug	516 EUR
Description: Mouse monoclonal Annexin V antibody
Annexin VI Antibody
21672-100ul	SAB	100ul	302.4 EUR
Annexin VI Antibody
21672-50ul	SAB	50ul	224.4 EUR
Annexin A1 antibody
22818-100ul	SAB	100ul	468 EUR
Annexin V antibody
20R-1522	Fitzgerald	100 ug	781.2 EUR
Description: Rabbit polyclonal Annexin V antibody
Annexin A5 Antibody
39410-100ul	SAB	100ul	468 EUR
Annexin A2 Antibody
39291-100ul	SAB	100ul	468 EUR
Annexin A10 Peptide
45-255P	ProSci	0.1 mg	405.6 EUR
Description: Annexin A10 / Annexin 14 Peptide
Annexin A6 antibody
70R-31098	Fitzgerald	100 ug	392.4 EUR
Description: Rabbit polyclonal Annexin A6 antibody
Annexin A2 Antibody
AF5420	Affbiotech	200ul	420 EUR
Annexin V antibody
70R-11770	Fitzgerald	100 ug	632.4 EUR
Description: Rabbit polyclonal Annexin V antibody
Annexin V Antibody
49376-100ul	SAB	100ul	399.6 EUR
Annexin V Antibody
49376-50ul	SAB	50ul	286.8 EUR
Annexin A2 Antibody
49559-100ul	SAB	100ul	399.6 EUR
Annexin A2 Antibody
49559-50ul	SAB	50ul	286.8 EUR
Annexin A7 antibody
70R-1680	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A7 antibody raised against the N terminal of ANXA7
Annexin A1 antibody
70R-1703	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A1 antibody raised against the N terminal of ANXA1
Annexin A1 antibody
70R-13525	Fitzgerald	100 ul	548.4 EUR
Description: Affinity purified Rabbit polyclonal Annexin A1 antibody
Annexin I antibody
70R-13689	Fitzgerald	100 ug	386.4 EUR
Description: Affinity purified Rabbit polyclonal Annexin I antibody
Annexin IV antibody
70R-13690	Fitzgerald	100 ug	386.4 EUR
Description: Affinity purified Rabbit polyclonal Annexin IV antibody
Annexin V antibody
70R-13691	Fitzgerald	100 ug	386.4 EUR
Description: Affinity purified Rabbit polyclonal Annexin V antibody
Annexin A2 antibody
70R-13890	Fitzgerald	100 ug	386.4 EUR
Description: Affinity purified Rabbit polyclonal Annexin A2 antibody
Annexin A6 antibody
70R-13975	Fitzgerald	100 ug	386.4 EUR
Description: Affinity purified Rabbit polyclonal Annexin A6 antibody
Annexin A8 antibody
70R-14039	Fitzgerald	100 ug	418.8 EUR
Description: Affinity purified Rabbit polyclonal Annexin A8 antibody
Annexin A3 antibody
70R-14049	Fitzgerald	100 ug	386.4 EUR
Description: Affinity purified Rabbit polyclonal Annexin A3 antibody
Annexin A2 antibody
70R-15166	Fitzgerald	100 ug	392.4 EUR
Description: Rabbit polyclonal Annexin A2 antibody
Annexin A5 antibody
70R-15224	Fitzgerald	100 ug	392.4 EUR
Description: Rabbit polyclonal Annexin A5 antibody
Annexin A7 antibody
70R-1667	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A7 antibody raised against the N terminal of ANXA7
Annexin A5 antibody
70R-1668	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A5 antibody raised against the N terminal of ANXA5
Annexin A5 antibody
70R-1669	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A5 antibody raised against the N terminal of ANXA5
Annexin A6 antibody
70R-1672	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A6 antibody raised against the C terminal of ANXA6
Annexin A6 antibody
70R-1673	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A6 antibody raised against the N terminal of ANXA6
Annexin A4 antibody
70R-1676	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A4 antibody raised against the N terminal of ANXA4
Annexin A3 antibody
70R-1677	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A3 antibody raised against the N terminal of ANXA3
Annexin A3 antibody
70R-1678	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A3 antibody raised against the C terminal of ANXA3
Annexin A2 antibody
70R-1679	Fitzgerald	100 ug	452.4 EUR
Description: Rabbit polyclonal Annexin A2 antibody raised against the C terminal of ANXA2
Annexin A4 antibody
70R-6041	Fitzgerald	50 ug	560.4 EUR
Description: Rabbit polyclonal Annexin A4 antibody raised against the middle region of ANXA4
Annexin A2 antibody
70R-51447	Fitzgerald	100 ul	344.4 EUR
Description: Purified Polyclonal Annexin A2 antibody
Annexin A1 antibody
70R-49368	Fitzgerald	100 ul	292.8 EUR
Description: Purified Polyclonal Annexin A1 antibody
Annexin A2 antibody
70R-49369	Fitzgerald	100 ul	292.8 EUR
Description: Purified Polyclonal Annexin A2 antibody
Annexin A3 antibody
70R-49370	Fitzgerald	100 ul	292.8 EUR
Description: Purified Polyclonal Annexin A3 antibody
Annexin A6 antibody
70R-49371	Fitzgerald	100 ul	292.8 EUR
Description: Purified Polyclonal Annexin A6 antibody
Annexin V Antibody
3357-100	Biovision	each	464.4 EUR
Annexin V Antibody
3357-30T	Biovision	each	175.2 EUR
Annexin XI Antibody
35334-100ul	SAB	100ul	468 EUR
Annexin A6 Antibody
33322-100ul	SAB	100ul	302.4 EUR
Annexin A6 Antibody
33322-50ul	SAB	50ul	224.4 EUR
Annexin A3 Antibody
48531-100ul	SAB	100ul	399.6 EUR
Annexin A3 Antibody
48531-50ul	SAB	50ul	286.8 EUR
Annexin IV Antibody
49926-100ul	SAB	100ul	399.6 EUR
Annexin IV Antibody
49926-50ul	SAB	50ul	286.8 EUR
Annexin A6 Antibody
ABF0116	Lifescience Market	100 ug	525.6 EUR
Annexin?I Antibody
ABF5154	Lifescience Market	100 ug	525.6 EUR
Annexin II Antibody
ABF5171	Lifescience Market	100 ug	525.6 EUR
Annexin A5 Antibody
1-CSB-PA001846HA01EQC	Cusabio	380.40 EUR 402.00 EUR	100ug 50ug
Description: A polyclonal antibody against Annexin A5. Recognizes Annexin A5 from Cynops pyrrhogaster. This antibody is Unconjugated. Tested in the following application: ELISA
Annexin V Antibody
F49706-0.08ML	NSJ Bioreagents	0.08 ml	140.25 EUR
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.
Annexin V Antibody
F49706-0.4ML	NSJ Bioreagents	0.4 ml	322.15 EUR
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.
Annexin V Antibody
F49707-0.08ML	NSJ Bioreagents	0.08 ml	140.25 EUR
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt]
Annexin V Antibody
F49707-0.4ML	NSJ Bioreagents	0.4 ml	322.15 EUR
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt]
Annexin A1 Antibody
F49712-0.08ML	NSJ Bioreagents	0.08 ml	140.25 EUR
Description: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
Annexin A1 Antibody
F49712-0.4ML	NSJ Bioreagents	0.4 ml	322.15 EUR
Description: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
Annexin V antibody
PAab09988	Lifescience Market	100 ug	463.2 EUR
Annexin A1 Antibody
P1024-01m	SAB	0.1m	242.4 EUR
Annexin A1 Antibody
P1024-1ml	SAB	1ml	529.2 EUR
Annexin A1 Antibody
R30173	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin I, also known as lipocortin I(Lipo1), belongs to the family of annexins. These proteins are though to control the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes. In two lipocortins(I and II) a short amino-terminal sequence distinct from the core structure has potential regulatory functions which are dependent on its phosphorylation state. The gene in the mouse encodes a protein of 346 amino acid residues. Mouse Lipo1 gene spans about 17 kb and is divided into 13 exons. Annexin I gene, mapped to 9q11-q22, is located on mouse chromosome 19. Annexin I acts through the formyl peptide receptor on human neutrophils. Peptides derived from the unique N-terminal domain of annexin I serve as FPR ligands and trigger different signaling pathways in a dose-dependent manner.
Annexin V Antibody
R30176	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin V is also know as endonnexin II (ENX2),or placental protein 4 (PP4). It is a member of the family of Ca(2+)-dependent phospholipid binding proteins, known as annexins. It bind to the phospholipids that are preferentially located on the cytosolic face of the plasma membrane. Annexin V has a relative molecular weight of about 35,000. The gene lies on mouse chromosome 3 in close linkage with the fibroblast growth factor 2(basic) gene and is syntenic with other genes known to have orthologous counterparts on human chromosome 4q. The cDNA encoded a protein of 320 amino acid residues. A single mRNA, approximately 1.6 kb long, was found to be expressed in human cell lines and placenta. It is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Annexin A2 Antibody
R30414	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. The ANXA2 gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Richard et al.(1994) presented an integration of the physical, expression, and genetic maps of human chromosome 15. They placed the ANXA2 gene in their region IV, i.e., 15q21-q22, thus confirming the previous localization.
Annexin VI Antibody
R30506	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin VI (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca(2+)-dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization.The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal.Ca(2+)-dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion
Annexin A3 Antibody
R30583	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The gene contains 13 exons and spans 58 kb of genomic DNA and is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
Annexin V Antibody
R31475	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin V or A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. This protein is an anticoagulant protein, it can form a shield around negatively-charged phospholipid molecules, the formation of an Annexin V shield blocks the entry of phospholipids into coagulation (clotting) reactions. Annexin AV can also act as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Annexin A1 Antibody
R31548	NSJ Bioreagents	100 ug	356.15 EUR
Description: ANXA1, also known as Lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. It belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.
Annexin A3 Antibody
R31948	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans 58 kb of genomic DNA. The Annexin A3 gene is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
Annexin IV Antibody
R32677	NSJ Bioreagents	100ug	356.15 EUR
Description: ANXA4 (Annexin A4), also known as ANX4, is a protein that in humans is encoded by the ANXA4 gene. It belongs to the annexin family of calcium-dependent phospholipid binding proteins. By PCR analysis of somatic cell hybrids and in situ hybridization with a cDNA probe, the human ANXA4 gene is mapped to chromosome 2p13. Isolated from human placenta, ANXA4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. And ANXA4 is almost exclusively expressed in epithelial cells.
Annexin A1 Antibody
R33307-100UG	NSJ Bioreagents	100 ug	339.15 EUR
Description: Additional name(s) for this target protein: ANXA1
Annexin A1 Antibody
V3736-100UG	NSJ Bioreagents	100 ug	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V3736-20UG	NSJ Bioreagents	20 ug	153.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V3736SAF-100UG	NSJ Bioreagents	100 ug	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V3741-100UG	NSJ Bioreagents	100 ug	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V3741-20UG	NSJ Bioreagents	20 ug	153.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V3741IHC-7ML	NSJ Bioreagents	7 ml	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V3741SAF-100UG	NSJ Bioreagents	100 ug	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V7283-100UG	NSJ Bioreagents	100 ug	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V7283-20UG	NSJ Bioreagents	20 ug	153.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V7283IHC-7ML	NSJ Bioreagents	7 ml	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin A1 Antibody
V7283SAF-100UG	NSJ Bioreagents	100 ug	349.3 EUR
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
Annexin V Antibody
RQ5261	NSJ Bioreagents	100ul	356.15 EUR
Description: The protein encoded by the ANXA5 gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. [RefSeq]
Annexin VI Antibody
RQ6590	NSJ Bioreagents	100ug	356.15 EUR
Description: Annexin A6 (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca(2+)-dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization. The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal. Ca(2+)-dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion.
Annexin VI Antibody
RQ4425	NSJ Bioreagents	100 ug	356.15 EUR
Description: Annexin A6 (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca(2+)-dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization. The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal. Ca(2+)-dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion.
Annexin A3 Antibody
RQ4892	NSJ Bioreagents	100ug	356.15 EUR
Description: Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans 58 kb of genomic DNA. The Annexin A3 gene is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
Annexin A6 Antibody
AF0116-100ul	Affinity Biosciences	100ul	280 EUR
Annexin A6 Antibody
AF0116-200ul	Affinity Biosciences	200ul	350 EUR
Annexin A7 Antibody
E38PA3769	EnoGene	100ul	225 EUR
Description: Available in various conjugation types.
Annexin A1 Antibody
E38PA4563	EnoGene	100ul	225 EUR
Description: Available in various conjugation types.
Annexin A1 Antibody
DF6254	Affinity Biosciences	100ul	280 EUR
Description: Human,Mouse,Rat
Annexin A2 Antibody
DF6468	Affinity Biosciences	100ul	280 EUR
Description: Human,Mouse,Rat
Annexin V Antibody
DF6580	Affinity Biosciences	100ul	280 EUR
Description: Human,Mouse,Rat
Annexin IV Antibody
DF8068	Affinity Biosciences	100ul	280 EUR
Description: Human,Mouse
Annexin A1 Antibody
AF5154-100ul	Affinity Biosciences	100ul	280 EUR
Annexin A1 Antibody
AF5154-200ul	Affinity Biosciences	200ul	350 EUR
Annexin A2 Antibody
AF5171-100ul	Affinity Biosciences	100ul	280 EUR
Annexin A2 Antibody
AF5171-200ul	Affinity Biosciences	200ul	350 EUR
Annexin A1 Antibody
AF5328-100ul	Affinity Biosciences	100ul	280 EUR
Annexin A1 Antibody
AF5328-200ul	Affinity Biosciences	200ul	350 EUR
Annexin A1 Antibody
DF6254-100ul	Affinity Biosciences	100ul	280 EUR

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Collectively, these data suggest that MEHP induces oxidative stress by disrupting the activities of antioxidant enzymes. This may lead to decreased expression of cell-cycle regulators and antiapoptotic regulators and increased expression of proapoptotic factors, which then may lead to inhibition of follicle growth.