Transcriptome profiling and pathway analysis of the effects of mono-(2-ethylhexyl) phthalate in mouse Sertoli cells.
Phthalates are confirmed to have poisonous effects on the reproductive system and are prone to have additional damaging actions in people. The current examine explored the molecular mechanisms of the poisonous impact of mono-(2-ethylhexyl) phthalate (MEHP) on mouse Sertoli cells.
Cell apoptosis and proliferation assays had been used to evaluate the effects of MEHP on the TM4 Sertoli cell line derived from mouse testes. TM4 cells had been handled with two doses of MEHP or left untreated as a management group, adopted by RNA extraction and analysis utilizing high-throughput transcriptome sequencing know-how. The gene expression profile obtained was then subjected to a bioinformatics analysis to discover the molecular mechanisms of reproductive toxicity.
The outcomes revealed that 528 and 269 genes had been upregulated in the high- and low-dose MEHP teams of cells in contrast with the management group, whereas 148 and 173 genes had been downregulated. Gene ontology (GO) analysis indicated that the otherwise expressed genes had been related with the GO time period ‘extracellular area’ of the mobile part area in the excessive and low MEHP teams.
Annexin V-PE/7-AAD Apoptosis Kit |
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E-CK-A216-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-PE/7-AAD Apoptosis Kit |
|||
E-CK-A216-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-PE/7-AAD Apoptosis Kit |
|||
E-CK-A216-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-PE/7-AAD Apoptosis Kit |
|||
E-CK-A216-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-APC/7-AAD Apoptosis Kit |
|||
E-CK-A218-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-APC/7-AAD Apoptosis Kit |
|||
E-CK-A218-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-APC/7-AAD Apoptosis Kit |
|||
E-CK-A218-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-APC/7-AAD Apoptosis Kit |
|||
E-CK-A218-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-FITC/7-AAD Apoptosis Kit |
|||
E-CK-A212-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-FITC/7-AAD Apoptosis Kit |
|||
E-CK-A212-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-FITC/7-AAD Apoptosis Kit |
|||
E-CK-A212-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-FITC/7-AAD Apoptosis Kit |
|||
E-CK-A212-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-EGFP/7-AAD Apoptosis Kit |
|||
E-CK-A220-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-EGFP/7-AAD Apoptosis Kit |
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E-CK-A220-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-EGFP/7-AAD Apoptosis Kit |
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E-CK-A220-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-EGFP/7-AAD Apoptosis Kit |
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E-CK-A220-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V -AF555/ 7-AAD apoptosis kit |
|||
EGQ0023 | EnoGene | 50T | 225 EUR |
Annexin V-FITC/7-AAD Apoptosis Kit |
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K1139-100 | ApexBio | 100assays | 184 EUR |
Description: Annexin V-FITC/7-AAD双染细胞凋亡检测试剂盒, 可在10-20分钟内检测细胞凋亡和坏死 |
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Annexin V-FITC/7-AAD Apoptosis Kit |
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K1139-20 | ApexBio | 20assays | 58 EUR |
Description: Annexin V-FITC/7-AAD双染细胞凋亡检测试剂盒, 可在10-20分钟内检测细胞凋亡和坏死 |
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Annexin V-FITC/7-AAD Apoptosis Kit |
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K1139-50 | ApexBio | 50assays | 116 EUR |
Description: Annexin V-FITC/7-AAD双染细胞凋亡检测试剂盒, 可在10-20分钟内检测细胞凋亡和坏死 |
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Annexin V-AF647/7-AAD Apoptosis Kit |
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E-CK-A214-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-AF647/7-AAD Apoptosis Kit |
|||
E-CK-A214-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-AF647/7-AAD Apoptosis Kit |
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E-CK-A214-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-AF647/7-AAD Apoptosis Kit |
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E-CK-A214-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-EV450/7-AAD Apoptosis Kit |
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E-CK-A234-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-EV450/7-AAD Apoptosis Kit |
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E-CK-A234-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-EV450/7-AAD Apoptosis Kit |
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E-CK-A234-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-EV450/7-AAD Apoptosis Kit |
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E-CK-A234-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-EV500/7-AAD Apoptosis Kit |
|||
E-CK-A236-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-EV500/7-AAD Apoptosis Kit |
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E-CK-A236-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-EV500/7-AAD Apoptosis Kit |
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E-CK-A236-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-EV500/7-AAD Apoptosis Kit |
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E-CK-A236-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-AF488/7-AAD Apoptosis Kit |
|||
E-CK-A238-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-AF488/7-AAD Apoptosis Kit |
|||
E-CK-A238-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-AF488/7-AAD Apoptosis Kit |
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E-CK-A238-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-AF488/7-AAD Apoptosis Kit |
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E-CK-A238-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-ER780/7-AAD Apoptosis Kit |
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E-CK-A240-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-ER780/7-AAD Apoptosis Kit |
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E-CK-A240-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-ER780/7-AAD Apoptosis Kit |
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E-CK-A240-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-ER780/7-AAD Apoptosis Kit |
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E-CK-A240-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-Cyanine5/7-AAD Apoptosis Kit |
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E-CK-A222-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-Cyanine5/7-AAD Apoptosis Kit |
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E-CK-A222-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-Cyanine5/7-AAD Apoptosis Kit |
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E-CK-A222-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-Cyanine5/7-AAD Apoptosis Kit |
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E-CK-A222-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V (PE) / 7-AAD Apoptosis Detection Kit (PE) |
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abx090609-100tests | Abbexa | 100 tests | 718.8 EUR |
Annexin A5 (Annexin V)-FITC |
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MC-251 | Kamiya Biomedical Company | VAA-33 | Ask for price |
Annexin A5 (Annexin V)-Biotin |
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MC-252 | Kamiya Biomedical Company | VAA-33 | Ask for price |
Annexin V |
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E8ET1702-62 | EnoGene | 100ul | 275 EUR |
Description: Available in various conjugation types. |
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Annexin V |
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Annv | Clemente Associates LLC | 2 ML | 367.5 EUR |
Annexin V |
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ANXVCFB-200T | ImmunoStep | 200 test | 350.9 EUR |
Description: Annexin V conjugate in the selected fluorochrome |
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Annexin V |
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ANXVDY-200T | ImmunoStep | 200 test | 287.1 EUR |
Description: Annexin V conjugate in the selected fluorochrome |
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Annexin V |
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ANXVF-200T | ImmunoStep | 200 test | 259.6 EUR |
Description: Annexin V conjugate in the selected fluorochrome |
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Annexin V |
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ANXVPE-200T | ImmunoStep | 200 test | 287.1 EUR |
Description: Annexin V conjugate in the selected fluorochrome |
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Annexin V |
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abx095275-100l | Abbexa | 100 µl | 443.75 EUR |
Annexin V |
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abx095275-1ml | Abbexa | 1 ml | Ask for price |
Annexin V |
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abx095275-200l | Abbexa | 200 µl | Ask for price |
Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit |
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E-CK-A228-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit |
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E-CK-A228-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit |
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E-CK-A228-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit |
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E-CK-A228-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V 647 |
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E16FXP023a-100T | EnoGene | 100 tests | 433.33 EUR |
Description: Available in various conjugation types. |
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Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit |
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E-CK-A230-100Assays | Elabscience Biotech | 100 Assays | 260 EUR |
Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit |
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E-CK-A230-200Assays | Elabscience Biotech | 200 Assays | 398 EUR |
Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit |
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E-CK-A230-20Assays | Elabscience Biotech | 20 Assays | 75 EUR |
Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit |
|||
E-CK-A230-50Assays | Elabscience Biotech | 50 Assays | 150 EUR |
Annexin V-PE/7-AAD Apoptosis Detection Kit |
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DLSM0246 | DL Develop | 100 Assays | Ask for price |
Description: Detection phosphatidylserine on the outer leaflet of the cell membrane using flow cytometry. |
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Annexin V-PE/7-AAD Apoptosis Detection Kit |
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E28LS4004-100 | EnoGene | 100T | 793.65 EUR |
Annexin V-PE/7-AAD Apoptosis Detection Kit |
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E28LS4004-20 | EnoGene | 20T | 279.37 EUR |
Annexin V-PE/7-AAD Apoptosis Detection Kit |
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E28LS4004-50 | EnoGene | 50T | 507.94 EUR |
Annexin V-PE/7-AAD Apoptosis Detection Kit |
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A213-01 | Vazyme | 50 rxn | 96.5 EUR |
Annexin V-PE/7-AAD Apoptosis Detection Kit |
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A213-02 | Vazyme | 100 rxn | 145 EUR |
Annexin V (APC) / 7-AAD Apoptosis Detection Kit |
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abx090607-100l | Abbexa | 100 µl | 587.5 EUR |
Annexin V (APC) / 7-AAD Apoptosis Detection Kit |
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abx090607-1ml | Abbexa | 1 ml | Ask for price |
Annexin V (APC) / 7-AAD Apoptosis Detection Kit |
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abx090607-200l | Abbexa | 200 µl | Ask for price |
Annexin V (FITC) / 7-AAD Apoptosis Detection Kit |
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abx090603-100tests | Abbexa | 100 tests | 594 EUR |
Annexin A5/Annexin V Rabbit mAb |
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A9262 | Abclonal | 200μL | 213.2 EUR |
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 165-225 of human CD79a (NP_001774.1). |
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Annexin A5 (Annexin V) (VAC-alpha) |
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MC-250 | Kamiya Biomedical Company | VAA-33 | Ask for price |
Annexin V (APC) / 7-AAD Apoptosis Detection Kit (APC) |
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abx090607-100tests | Abbexa | 100 tests | 811.2 EUR |
Annexin V (PE) |
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abx090613-100tests | Abbexa | 100 tests | 644.4 EUR |
Annexin V PE |
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EXB0027 | ExBio | 100 tests | 198 EUR |
Annexin V (APC) |
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abx090615-100tests | Abbexa | 100 tests | 718.8 EUR |
Annexin V APC |
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EXB0028 | ExBio | 100 tests | 198 EUR |
Annexin V (APC) |
|||
abx090615-100l | Abbexa | 100 µl | 537.5 EUR |
Annexin V (APC) |
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abx090615-1ml | Abbexa | 1 ml | Ask for price |
Annexin V (APC) |
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abx090615-200l | Abbexa | 200 µl | Ask for price |
Annexin V (FITC) |
|||
abx090611-100tests | Abbexa | 100 tests | 510 EUR |
Annexin V- FITC |
|||
E16FXP018a-100T | EnoGene | 100 tests | 400 EUR |
Description: Available in various conjugation types. |
|||
Annexin V FITC |
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EXB0024 | ExBio | 100 tests | 165 EUR |
Annexin V, Human |
|||
E34M143H | EnoGene | 5 μg | 155 EUR |
Annexin V siRNA |
|||
20-abx900343 | Abbexa |
|
|
Annexin V siRNA |
|||
20-abx907673 | Abbexa |
|
|
Annexin V siRNA |
|||
20-abx907674 | Abbexa |
|
|
Annexin V, sulforhodamine 101 conjugate (Texas-Red Annexin V) |
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29002 | Biotium | 0.5ML | 332.4 EUR |
Description: Minimum order quantity: 1 unit of 0.5ML |
|||
Annexin V-iFluor 594 + 7-AAD Apoptosis Detection Reagent |
|||
E34M002D | EnoGene | 50 rxn | 225 EUR |
Annexin V antibody |
|||
10R-7939 | Fitzgerald | 100 ug | 444 EUR |
Description: Mouse monoclonal Annexin V antibody |
|||
Annexin V antibody |
|||
20R-1522 | Fitzgerald | 100 ug | 781.2 EUR |
Description: Rabbit polyclonal Annexin V antibody |
|||
Annexin V Antibody |
|||
3357-100 | Biovision | each | 464.4 EUR |
Annexin V Antibody |
|||
3357-30T | Biovision | each | 175.2 EUR |
Annexin V Antibody |
|||
49376 | SAB | 100ul | 499 EUR |
Annexin V Antibody |
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49376-100ul | SAB | 100ul | 399.6 EUR |
Annexin V Antibody |
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49376-50ul | SAB | 50ul | 286.8 EUR |
Annexin V Antibody |
|||
E2300787 | EnoGene | 100ug | 225 EUR |
Description: Available in various conjugation types. |
|||
Annexin V Antibody |
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DF6580 | Affbiotech | 200ul | 420 EUR |
Annexin V Antibody |
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DF6580-100ul | Affinity Biosciences | 100ul | 280 EUR |
Annexin V Antibody |
|||
DF6580-200ul | Affinity Biosciences | 200ul | 350 EUR |
Annexin V antibody |
|||
E39-09988 | EnoGene | 100ug/100ul | 225 EUR |
Description: Available in various conjugation types. |
|||
Annexin V Antibody |
|||
E300518 | EnoGene | 100ug/200ul | 275 EUR |
Description: Available in various conjugation types. |
|||
Annexin V antibody |
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CAF50033-100ug | Biomatik Corporation | 100ug | 312 EUR |
Annexin V antibody |
|||
CAF50425-100ug | Biomatik Corporation | 100ug | 338 EUR |
Annexin V antibody |
|||
70R-13691 | Fitzgerald | 100 ug | 519 EUR |
Description: Affinity purified Rabbit polyclonal Annexin V antibody |
|||
Annexin V antibody |
|||
70R-11770 | Fitzgerald | 100 ug | 447 EUR |
Description: Rabbit polyclonal Annexin V antibody |
|||
Annexin V Antibody |
|||
GWB-70457E | GenWay Biotech | 0.1 mg | Ask for price |
Annexin V Antibody |
|||
GWB-BA41FA | GenWay Biotech | 0.1 mg | Ask for price |
Annexin V Antibody |
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F49706-0.08ML | NSJ Bioreagents | 0.08 ml | 140.25 EUR |
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. |
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Annexin V Antibody |
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F49706-0.4ML | NSJ Bioreagents | 0.4 ml | 322.15 EUR |
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. |
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Annexin V Antibody |
|||
F49707-0.08ML | NSJ Bioreagents | 0.08 ml | 140.25 EUR |
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt] |
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Annexin V Antibody |
|||
F49707-0.4ML | NSJ Bioreagents | 0.4 ml | 322.15 EUR |
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt] |
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Annexin V antibody |
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PAab09988 | Lifescience Market | 100 ug | 463.2 EUR |
Annexin V Antibody |
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R30176 | NSJ Bioreagents | 100 ug | 356.15 EUR |
Description: Annexin V is also know as endonnexin II (ENX2),or placental protein 4 (PP4). It is a member of the family of Ca(2+)-dependent phospholipid binding proteins, known as annexins. It bind to the phospholipids that are preferentially located on the cytosolic face of the plasma membrane. Annexin V has a relative molecular weight of about 35,000. The gene lies on mouse chromosome 3 in close linkage with the fibroblast growth factor 2(basic) gene and is syntenic with other genes known to have orthologous counterparts on human chromosome 4q. The cDNA encoded a protein of 320 amino acid residues. A single mRNA, approximately 1.6 kb long, was found to be expressed in human cell lines and placenta. It is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
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Annexin V Antibody |
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R31475 | NSJ Bioreagents | 100 ug | 356.15 EUR |
Description: Annexin V or A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. This protein is an anticoagulant protein, it can form a shield around negatively-charged phospholipid molecules, the formation of an Annexin V shield blocks the entry of phospholipids into coagulation (clotting) reactions. Annexin AV can also act as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
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Annexin V Antibody |
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RQ5261 | NSJ Bioreagents | 100ul | 356.15 EUR |
Description: The protein encoded by the ANXA5 gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. [RefSeq] |
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Annexin V, Recombinant |
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20014 | AAT Bioquest | 100 ug | 227 EUR |
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. |
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Annexin V, Recombinant |
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20014-100ug | AAT Bioquest | 100 ug | 222 EUR |
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. |
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Annexin V, Recombinant |
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20015 | AAT Bioquest | 1 mg | 1540 EUR |
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. |
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Annexin V, Recombinant |
|||
20015-1mg | AAT Bioquest | 1 mg | 1509 EUR |
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. |
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Annexin V Mouse mAb |
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E2221242 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
|||
Annexin V ELISA kit |
|||
55R-IB49646 | Fitzgerald | 96 wells | 1413.6 EUR |
Description: ELISA kit for the detection of Annexin V in the research laboratory |
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Annexin V ELISA kit |
|||
55R-ORG643 | Fitzgerald | 96 wells | 390 EUR |
Description: ELISA kit for the detection of Annexin V in the research laboratory |
|||
Annexin V Mouse mAb |
|||
E2222039 | EnoGene | 100ul | 255 EUR |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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Annexin V Rabbit mAb |
|||
59326 | SAB | 100ul | 339 EUR |
Annexin V Rabbit pAb |
|||
E2381706 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
|||
Annexin V Rabbit pAb |
|||
E2382841 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
|||
Annexin V Rabbit mAb |
|||
E2R22841 | EnoGene | 100ul | 255 EUR |
Description: Available in various conjugation types. |
|||
Annexin V Dyomics 647 |
|||
EXB0023 | ExBio | 100 tests | 220 EUR |
Annexin V-PE Reagent |
|||
1014-1000 | Biovision | each | 1358.4 EUR |
Annexin V-PE Reagent |
|||
1014-200 | Biovision | each | 483.6 EUR |
Annexin V-PE Reagent |
|||
E-CK-A115-100Tests | Elabscience Biotech | 100 Tests | 190 EUR |
Annexin V-PE Reagent |
|||
E-CK-A115-200Tests | Elabscience Biotech | 200 Tests | 298 EUR |
Annexin V-PE Reagent |
|||
E-CK-A115-500Tests | Elabscience Biotech | 500 Tests | 660 EUR |
Annexin V-PE Reagent |
|||
E-CK-A115-50Tests | Elabscience Biotech | 50 Tests | 110 EUR |
Annexin V Solution (PE) |
|||
abx095273-100l | Abbexa | 100 µl | 350 EUR |
Annexin V Solution (PE) |
|||
abx095273-1ml | Abbexa | 1 ml | Ask for price |
Annexin V Solution (PE) |
|||
abx095273-200l | Abbexa | 200 µl | Ask for price |
Annexin V-Cy3 Reagent |
|||
1002-1000 | Biovision | each | 1358.4 EUR |
Annexin V-Cy3 Reagent |
|||
1002-200 | Biovision | each | 483.6 EUR |
Annexin V-Cy5 Reagent |
|||
1013-1000 | Biovision | each | 1358.4 EUR |
Annexin V-Cy5 Reagent |
|||
1013-200 | Biovision | each | 483.6 EUR |
Annexin V, FITC Labeled |
|||
20030 | AAT Bioquest | 100 tests | 227 EUR |
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. |
|||
Annexin V, FITC Labeled |
|||
20030-100tests | AAT Bioquest | 100 tests | 222 EUR |
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium. |
|||
Annexin V-APC Reagent |
|||
E-CK-A117-100Tests | Elabscience Biotech | 100 Tests | 190 EUR |
Annexin V-APC Reagent |
|||
E-CK-A117-200Tests | Elabscience Biotech | 200 Tests | 298 EUR |
Annexin V-APC Reagent |
|||
E-CK-A117-500Tests | Elabscience Biotech | 500 Tests | 660 EUR |
Annexin V-APC Reagent |
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E-CK-A117-50Tests | Elabscience Biotech | 50 Tests | 110 EUR |
Active Annexin V (ANXA5) |
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APA259Hu61 | Cloud-Clone | 10ug | 331 EUR |
Active Annexin V (ANXA5) |
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APA259Mu01 | Cloud-Clone | 10ug | 228 EUR |
Active Annexin V (ANXA5) |
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APA259Ra01 | Cloud-Clone | 10ug | 232 EUR |
Active Annexin V (ANXA5) |
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4-APA259Ra01 | Cloud-Clone |
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Description: Recombinant Rat Annexin V expressed in: E.coli |
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Active Annexin V (ANXA5) |
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RPU55516-100ug | Biomatik Corporation | 100ug | 918.5 EUR |
Active Annexin V (ANXA5) |
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RPU55516-1mg | Biomatik Corporation | 1mg | 3619.2 EUR |
Active Annexin V (ANXA5) |
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RPU55516-50ug | Biomatik Corporation | 50ug | 556.8 EUR |
Annexin V Solution (APC) |
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abx095274-100l | Abbexa | 100 µl | 350 EUR |
Compared with the management group, eight widespread pathway adjustments had been recognized in the high- and low-dose MEHP teams, together with ‘terpenoid spine biosynthesis’. Reverse transcription-quantitative polymerase chain response analysis was used to validation, and airtight effects had been noticed for sure genes. These outcomes present an essential foundation and experimental information for additional analysis into the mechanisms of phthalate-induced toxicity.
Mono-butyl phthalate-induced mouse testis damage is related to oxidative stress and down-regulated expression of Sox9 and Dazl.
Mono-butyl phthalate (MBP) has reproductive toxicity however the associated mechanisms haven’t been totally elucidated in vivo. We uncovered male Balb/c mice to MBP by gavage at doses of 0, 25, 50, 100, 200 mg/kg for 14 days, and then evaluated the testicular alterations at the histological and molecular ranges. MBP diminished mouse sperm rely together with sperm malformation and seminiferous tubule degeneration in a dose-dependent method.
MBP dosed at 200 mg/kg considerably elevated reactive oxygen species and malondialdehyde content material in mouse testes. High doses of MBP (200 mg/kg) additionally considerably diminished mRNA expressions of testis development and perform associated genes (Sox9 and Dazl). Our findings recommend that oxidative stress and down-regulated expression of Sox9 and Dazl might play essential roles in MBP-induced testis damage.
Mono-2-ethylhexyl phthalate stimulates androgen manufacturing however suppresses mitochondrial perform in mouse leydig cells with completely different steroidogenic potential.
Numerous research have reported on testicular toxicity of phthalates in completely different experimental paradigms and confirmed that Leydig cells (LCs) had been one of the foremost targets of phthalate actions. Adverse effects of phthalates on LCs steroidogenesis have been attributed to their metabolites, monophthalates.
This examine focuses on investigation whether or not LCs responsiveness to monophthalates motion is related to their potential to supply androgens. We discovered that of three monophthalates investigated [ie, mono-2-ethylhexyl phthalate (MEHP), mono-n-butyl phthalate, and mono-n-benzyl phthalate] solely MEHP brought about organic effects on the mouse LCs perform.
This monophthalate stimulated basal steroidogenesis related to upregulation of StAR protein expression with no impact on hCG-stimulated androgen manufacturing by LCs from CBA/Lac and C57BL/6j mouse genotypes had been noticed. Further, MEHP attenuated ATP manufacturing and elevated superoxide technology by each phenotypes of mouse LCs that indicated on mitochondrial dysfunction induced by the monophthalate.
All collectively, our information point out that MEHP-mediated stimulation of steroidogenesis and perturbation in mitochondrial perform usually are not related to the capability of the LCs to synthesize androgens. We recommend that this impact of MEHP noticed in LCs of rodent origin must be considered in analysis of earlier begin of puberty in boys and might spotlight a potential affect of phthalates on reproductive well being in males.