Transcriptome profiling and pathway analysis of the effects of mono-(2-ethylhexyl) phthalate in mouse Sertoli cells.

Phthalates are confirmed to have poisonous effects on the reproductive system and are prone to have additional damaging actions in people. The current examine explored the molecular mechanisms of the poisonous impact of mono-(2-ethylhexyl) phthalate (MEHP) on mouse Sertoli cells.

Cell apoptosis and proliferation assays had been used to evaluate the effects of MEHP on the TM4 Sertoli cell line derived from mouse testes. TM4 cells had been handled with two doses of MEHP or left untreated as a management group, adopted by RNA extraction and analysis utilizing high-throughput transcriptome sequencing know-how. The gene expression profile obtained was then subjected to a bioinformatics analysis to discover the molecular mechanisms of reproductive toxicity.

The outcomes revealed that 528 and 269 genes had been upregulated in the high- and low-dose MEHP teams of cells in contrast with the management group, whereas 148 and 173 genes had been downregulated. Gene ontology (GO) analysis indicated that the otherwise expressed genes had been related with the GO time period ‘extracellular area’ of the mobile part area in the excessive and low MEHP teams.

Annexin V-PE/7-AAD Apoptosis Kit

E-CK-A216-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-PE/7-AAD Apoptosis Kit

E-CK-A216-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-PE/7-AAD Apoptosis Kit

E-CK-A216-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-PE/7-AAD Apoptosis Kit

E-CK-A216-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-APC/7-AAD Apoptosis Kit

E-CK-A218-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-APC/7-AAD Apoptosis Kit

E-CK-A218-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-APC/7-AAD Apoptosis Kit

E-CK-A218-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-APC/7-AAD Apoptosis Kit

E-CK-A218-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-FITC/7-AAD Apoptosis Kit

E-CK-A212-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-FITC/7-AAD Apoptosis Kit

E-CK-A212-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-FITC/7-AAD Apoptosis Kit

E-CK-A212-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-FITC/7-AAD Apoptosis Kit

E-CK-A212-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-EGFP/7-AAD Apoptosis Kit

E-CK-A220-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-EGFP/7-AAD Apoptosis Kit

E-CK-A220-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-EGFP/7-AAD Apoptosis Kit

E-CK-A220-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-EGFP/7-AAD Apoptosis Kit

E-CK-A220-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V -AF555/ 7-AAD apoptosis kit

EGQ0023 EnoGene 50T 225 EUR

Annexin V-FITC/7-AAD Apoptosis Kit

K1139-100 ApexBio 100assays 184 EUR
Description: Annexin V-FITC/7-AAD双染细胞凋亡检测试剂盒, 可在10-20分钟内检测细胞凋亡和坏死

Annexin V-FITC/7-AAD Apoptosis Kit

K1139-20 ApexBio 20assays 58 EUR
Description: Annexin V-FITC/7-AAD双染细胞凋亡检测试剂盒, 可在10-20分钟内检测细胞凋亡和坏死

Annexin V-FITC/7-AAD Apoptosis Kit

K1139-50 ApexBio 50assays 116 EUR
Description: Annexin V-FITC/7-AAD双染细胞凋亡检测试剂盒, 可在10-20分钟内检测细胞凋亡和坏死

Annexin V-AF647/7-AAD Apoptosis Kit

E-CK-A214-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-AF647/7-AAD Apoptosis Kit

E-CK-A214-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-AF647/7-AAD Apoptosis Kit

E-CK-A214-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-AF647/7-AAD Apoptosis Kit

E-CK-A214-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-EV450/7-AAD Apoptosis Kit

E-CK-A234-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-EV450/7-AAD Apoptosis Kit

E-CK-A234-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-EV450/7-AAD Apoptosis Kit

E-CK-A234-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-EV450/7-AAD Apoptosis Kit

E-CK-A234-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-EV500/7-AAD Apoptosis Kit

E-CK-A236-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-EV500/7-AAD Apoptosis Kit

E-CK-A236-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-EV500/7-AAD Apoptosis Kit

E-CK-A236-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-EV500/7-AAD Apoptosis Kit

E-CK-A236-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-AF488/7-AAD Apoptosis Kit

E-CK-A238-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-AF488/7-AAD Apoptosis Kit

E-CK-A238-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-AF488/7-AAD Apoptosis Kit

E-CK-A238-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-AF488/7-AAD Apoptosis Kit

E-CK-A238-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-ER780/7-AAD Apoptosis Kit

E-CK-A240-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-ER780/7-AAD Apoptosis Kit

E-CK-A240-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-ER780/7-AAD Apoptosis Kit

E-CK-A240-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-ER780/7-AAD Apoptosis Kit

E-CK-A240-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-Cyanine5/7-AAD Apoptosis Kit

E-CK-A222-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-Cyanine5/7-AAD Apoptosis Kit

E-CK-A222-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-Cyanine5/7-AAD Apoptosis Kit

E-CK-A222-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-Cyanine5/7-AAD Apoptosis Kit

E-CK-A222-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V (PE) / 7-AAD Apoptosis Detection Kit (PE)

abx090609-100tests Abbexa 100 tests 718.8 EUR

Annexin A5 (Annexin V)-FITC

MC-251 Kamiya Biomedical Company VAA-33 Ask for price

Annexin A5 (Annexin V)-Biotin

MC-252 Kamiya Biomedical Company VAA-33 Ask for price

Annexin V

E8ET1702-62 EnoGene 100ul 275 EUR
Description: Available in various conjugation types.

Annexin V

Annv Clemente Associates LLC 2 ML 367.5 EUR

Annexin V

ANXVCFB-200T ImmunoStep 200 test 350.9 EUR
Description: Annexin V conjugate in the selected fluorochrome

Annexin V

ANXVDY-200T ImmunoStep 200 test 287.1 EUR
Description: Annexin V conjugate in the selected fluorochrome

Annexin V

ANXVF-200T ImmunoStep 200 test 259.6 EUR
Description: Annexin V conjugate in the selected fluorochrome

Annexin V

ANXVPE-200T ImmunoStep 200 test 287.1 EUR
Description: Annexin V conjugate in the selected fluorochrome

Annexin V

abx095275-100l Abbexa 100 µl 443.75 EUR

Annexin V

abx095275-1ml Abbexa 1 ml Ask for price

Annexin V

abx095275-200l Abbexa 200 µl Ask for price

Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit

E-CK-A228-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit

E-CK-A228-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit

E-CK-A228-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-PE/Cyanine7/7-AAD Apoptosis Kit

E-CK-A228-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V 647

E16FXP023a-100T EnoGene 100 tests 433.33 EUR
Description: Available in various conjugation types.

Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit

E-CK-A230-100Assays Elabscience Biotech 100 Assays 260 EUR

Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit

E-CK-A230-200Assays Elabscience Biotech 200 Assays 398 EUR

Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit

E-CK-A230-20Assays Elabscience Biotech 20 Assays 75 EUR

Annexin V-APC/Cyanine7/7-AAD Apoptosis Kit

E-CK-A230-50Assays Elabscience Biotech 50 Assays 150 EUR

Annexin V-PE/7-AAD Apoptosis Detection Kit

DLSM0246 DL Develop 100 Assays Ask for price
Description: Detection phosphatidylserine on the outer leaflet of the cell membrane using flow cytometry.

Annexin V-PE/7-AAD Apoptosis Detection Kit

E28LS4004-100 EnoGene 100T 793.65 EUR

Annexin V-PE/7-AAD Apoptosis Detection Kit

E28LS4004-20 EnoGene 20T 279.37 EUR

Annexin V-PE/7-AAD Apoptosis Detection Kit

E28LS4004-50 EnoGene 50T 507.94 EUR

Annexin V-PE/7-AAD Apoptosis Detection Kit

A213-01 Vazyme 50 rxn 96.5 EUR

Annexin V-PE/7-AAD Apoptosis Detection Kit

A213-02 Vazyme 100 rxn 145 EUR

Annexin V (APC) / 7-AAD Apoptosis Detection Kit

abx090607-100l Abbexa 100 µl 587.5 EUR

Annexin V (APC) / 7-AAD Apoptosis Detection Kit

abx090607-1ml Abbexa 1 ml Ask for price

Annexin V (APC) / 7-AAD Apoptosis Detection Kit

abx090607-200l Abbexa 200 µl Ask for price

Annexin V (FITC) / 7-AAD Apoptosis Detection Kit

abx090603-100tests Abbexa 100 tests 594 EUR

Annexin A5/Annexin V Rabbit mAb

A9262 Abclonal 200μL 213.2 EUR
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 165-225 of human CD79a (NP_001774.1).

Annexin A5 (Annexin V) (VAC-alpha)

MC-250 Kamiya Biomedical Company VAA-33 Ask for price

Annexin V (APC) / 7-AAD Apoptosis Detection Kit (APC)

abx090607-100tests Abbexa 100 tests 811.2 EUR

Annexin V (PE)

abx090613-100tests Abbexa 100 tests 644.4 EUR

Annexin V PE

EXB0027 ExBio 100 tests 198 EUR

Annexin V (APC)

abx090615-100tests Abbexa 100 tests 718.8 EUR

Annexin V APC

EXB0028 ExBio 100 tests 198 EUR

Annexin V (APC)

abx090615-100l Abbexa 100 µl 537.5 EUR

Annexin V (APC)

abx090615-1ml Abbexa 1 ml Ask for price

Annexin V (APC)

abx090615-200l Abbexa 200 µl Ask for price

Annexin V (FITC)

abx090611-100tests Abbexa 100 tests 510 EUR

Annexin V- FITC

E16FXP018a-100T EnoGene 100 tests 400 EUR
Description: Available in various conjugation types.

Annexin V FITC

EXB0024 ExBio 100 tests 165 EUR

Annexin V, Human

E34M143H EnoGene 5 μg 155 EUR

Annexin V siRNA

20-abx900343 Abbexa
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

Annexin V siRNA

20-abx907673 Abbexa
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

Annexin V siRNA

20-abx907674 Abbexa
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

Annexin V, sulforhodamine 101 conjugate (Texas-Red Annexin V)

29002 Biotium 0.5ML 332.4 EUR
Description: Minimum order quantity: 1 unit of 0.5ML

Annexin V-iFluor 594 + 7-AAD Apoptosis Detection Reagent

E34M002D EnoGene 50 rxn 225 EUR

Annexin V antibody

10R-7939 Fitzgerald 100 ug 444 EUR
Description: Mouse monoclonal Annexin V antibody

Annexin V antibody

20R-1522 Fitzgerald 100 ug 781.2 EUR
Description: Rabbit polyclonal Annexin V antibody

Annexin V Antibody

3357-100 Biovision each 464.4 EUR

Annexin V Antibody

3357-30T Biovision each 175.2 EUR

Annexin V Antibody

49376 SAB 100ul 499 EUR

Annexin V Antibody

49376-100ul SAB 100ul 399.6 EUR

Annexin V Antibody

49376-50ul SAB 50ul 286.8 EUR

Annexin V Antibody

E2300787 EnoGene 100ug 225 EUR
Description: Available in various conjugation types.

Annexin V Antibody

DF6580 Affbiotech 200ul 420 EUR

Annexin V Antibody

DF6580-100ul Affinity Biosciences 100ul 280 EUR

Annexin V Antibody

DF6580-200ul Affinity Biosciences 200ul 350 EUR

Annexin V antibody

E39-09988 EnoGene 100ug/100ul 225 EUR
Description: Available in various conjugation types.

Annexin V Antibody

E300518 EnoGene 100ug/200ul 275 EUR
Description: Available in various conjugation types.

Annexin V antibody

CAF50033-100ug Biomatik Corporation 100ug 312 EUR

Annexin V antibody

CAF50425-100ug Biomatik Corporation 100ug 338 EUR

Annexin V antibody

70R-13691 Fitzgerald 100 ug 519 EUR
Description: Affinity purified Rabbit polyclonal Annexin V antibody

Annexin V antibody

70R-11770 Fitzgerald 100 ug 447 EUR
Description: Rabbit polyclonal Annexin V antibody

Annexin V Antibody

GWB-70457E GenWay Biotech 0.1 mg Ask for price

Annexin V Antibody

GWB-BA41FA GenWay Biotech 0.1 mg Ask for price

Annexin V Antibody

F49706-0.08ML NSJ Bioreagents 0.08 ml 140.25 EUR
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.

Annexin V Antibody

F49706-0.4ML NSJ Bioreagents 0.4 ml 322.15 EUR
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.

Annexin V Antibody

F49707-0.08ML NSJ Bioreagents 0.08 ml 140.25 EUR
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt]

Annexin V Antibody

F49707-0.4ML NSJ Bioreagents 0.4 ml 322.15 EUR
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt]

Annexin V antibody

PAab09988 Lifescience Market 100 ug 463.2 EUR

Annexin V Antibody

R30176 NSJ Bioreagents 100 ug 356.15 EUR
Description: Annexin V is also know as endonnexin II (ENX2),or placental protein 4 (PP4). It is a member of the family of Ca(2+)-dependent phospholipid binding proteins, known as annexins. It bind to the phospholipids that are preferentially located on the cytosolic face of the plasma membrane. Annexin V has a relative molecular weight of about 35,000. The gene lies on mouse chromosome 3 in close linkage with the fibroblast growth factor 2(basic) gene and is syntenic with other genes known to have orthologous counterparts on human chromosome 4q. The cDNA encoded a protein of 320 amino acid residues. A single mRNA, approximately 1.6 kb long, was found to be expressed in human cell lines and placenta. It is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Annexin V Antibody

R31475 NSJ Bioreagents 100 ug 356.15 EUR
Description: Annexin V or A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. This protein is an anticoagulant protein, it can form a shield around negatively-charged phospholipid molecules, the formation of an Annexin V shield blocks the entry of phospholipids into coagulation (clotting) reactions. Annexin AV can also act as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Annexin V Antibody

RQ5261 NSJ Bioreagents 100ul 356.15 EUR
Description: The protein encoded by the ANXA5 gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. [RefSeq]

Annexin V, Recombinant

20014 AAT Bioquest 100 ug 227 EUR
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium.

Annexin V, Recombinant

20014-100ug AAT Bioquest 100 ug 222 EUR
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium.

Annexin V, Recombinant

20015 AAT Bioquest 1 mg 1540 EUR
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium.

Annexin V, Recombinant

20015-1mg AAT Bioquest 1 mg 1509 EUR
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium.

Annexin V Mouse mAb

E2221242 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Annexin V ELISA kit

55R-IB49646 Fitzgerald 96 wells 1413.6 EUR
Description: ELISA kit for the detection of Annexin V in the research laboratory

Annexin V ELISA kit

55R-ORG643 Fitzgerald 96 wells 390 EUR
Description: ELISA kit for the detection of Annexin V in the research laboratory

Annexin V Mouse mAb

E2222039 EnoGene 100ul 255 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Annexin V Rabbit mAb

59326 SAB 100ul 339 EUR

Annexin V Rabbit pAb

E2381706 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Annexin V Rabbit pAb

E2382841 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

Annexin V Rabbit mAb

E2R22841 EnoGene 100ul 255 EUR
Description: Available in various conjugation types.

Annexin V Dyomics 647

EXB0023 ExBio 100 tests 220 EUR

Annexin V-PE Reagent

1014-1000 Biovision each 1358.4 EUR

Annexin V-PE Reagent

1014-200 Biovision each 483.6 EUR

Annexin V-PE Reagent

E-CK-A115-100Tests Elabscience Biotech 100 Tests 190 EUR

Annexin V-PE Reagent

E-CK-A115-200Tests Elabscience Biotech 200 Tests 298 EUR

Annexin V-PE Reagent

E-CK-A115-500Tests Elabscience Biotech 500 Tests 660 EUR

Annexin V-PE Reagent

E-CK-A115-50Tests Elabscience Biotech 50 Tests 110 EUR

Annexin V Solution (PE)

abx095273-100l Abbexa 100 µl 350 EUR

Annexin V Solution (PE)

abx095273-1ml Abbexa 1 ml Ask for price

Annexin V Solution (PE)

abx095273-200l Abbexa 200 µl Ask for price

Annexin V-Cy3 Reagent

1002-1000 Biovision each 1358.4 EUR

Annexin V-Cy3 Reagent

1002-200 Biovision each 483.6 EUR

Annexin V-Cy5 Reagent

1013-1000 Biovision each 1358.4 EUR

Annexin V-Cy5 Reagent

1013-200 Biovision each 483.6 EUR

Annexin V, FITC Labeled

20030 AAT Bioquest 100 tests 227 EUR
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium.

Annexin V, FITC Labeled

20030-100tests AAT Bioquest 100 tests 222 EUR
Description: Annexins are a family of proteins that bind to phospholipid membranes in the presence of calcium.

Annexin V-APC Reagent

E-CK-A117-100Tests Elabscience Biotech 100 Tests 190 EUR

Annexin V-APC Reagent

E-CK-A117-200Tests Elabscience Biotech 200 Tests 298 EUR

Annexin V-APC Reagent

E-CK-A117-500Tests Elabscience Biotech 500 Tests 660 EUR

Annexin V-APC Reagent

E-CK-A117-50Tests Elabscience Biotech 50 Tests 110 EUR

Active Annexin V (ANXA5)

APA259Hu61 Cloud-Clone 10ug 331 EUR

Active Annexin V (ANXA5)

APA259Mu01 Cloud-Clone 10ug 228 EUR

Active Annexin V (ANXA5)

APA259Ra01 Cloud-Clone 10ug 232 EUR

Active Annexin V (ANXA5)

4-APA259Ra01 Cloud-Clone
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Annexin V expressed in: E.coli

Active Annexin V (ANXA5)

RPU55516-100ug Biomatik Corporation 100ug 918.5 EUR

Active Annexin V (ANXA5)

RPU55516-1mg Biomatik Corporation 1mg 3619.2 EUR

Active Annexin V (ANXA5)

RPU55516-50ug Biomatik Corporation 50ug 556.8 EUR

Annexin V Solution (APC)

abx095274-100l Abbexa 100 µl 350 EUR

Compared with the management group, eight widespread pathway adjustments had been recognized in the high- and low-dose MEHP teams, together with ‘terpenoid spine biosynthesis’. Reverse transcription-quantitative polymerase chain response analysis was used to validation, and airtight effects had been noticed for sure genes. These outcomes present an essential foundation and experimental information for additional analysis into the mechanisms of phthalate-induced toxicity.

Transcriptome profiling and pathway analysis of the effects of mono-(2-ethylhexyl) phthalate in mouse Sertoli cells.
Transcriptome profiling and pathway analysis of the effects of mono-(2-ethylhexyl) phthalate in mouse Sertoli cells.

Mono-butyl phthalate-induced mouse testis damage is related to oxidative stress and down-regulated expression of Sox9 and Dazl.

Mono-butyl phthalate (MBP) has reproductive toxicity however the associated mechanisms haven’t been totally elucidated in vivo. We uncovered male Balb/c mice to MBP by gavage at doses of 0, 25, 50, 100, 200 mg/kg for 14 days, and then evaluated the testicular alterations at the histological and molecular ranges. MBP diminished mouse sperm rely together with sperm malformation and seminiferous tubule degeneration in a dose-dependent method.

MBP dosed at 200 mg/kg considerably elevated reactive oxygen species and malondialdehyde content material in mouse testes. High doses of MBP (200 mg/kg) additionally considerably diminished mRNA expressions of testis development and perform associated genes (Sox9 and Dazl). Our findings recommend that oxidative stress and down-regulated expression of Sox9 and Dazl might play essential roles in MBP-induced testis damage.

Mono-2-ethylhexyl phthalate stimulates androgen manufacturing however suppresses mitochondrial perform in mouse leydig cells with completely different steroidogenic potential.

Numerous research have reported on testicular toxicity of phthalates in completely different experimental paradigms and confirmed that Leydig cells (LCs) had been one of the foremost targets of phthalate actions. Adverse effects of phthalates on LCs steroidogenesis have been attributed to their metabolites, monophthalates.

This examine focuses on investigation whether or not LCs responsiveness to monophthalates motion is related to their potential to supply androgens. We discovered that of three monophthalates investigated [ie, mono-2-ethylhexyl phthalate (MEHP), mono-n-butyl phthalate, and mono-n-benzyl phthalate] solely MEHP brought about organic effects on the mouse LCs perform.

This monophthalate stimulated basal steroidogenesis related to upregulation of StAR protein expression with no impact on hCG-stimulated androgen manufacturing by LCs from CBA/Lac and C57BL/6j mouse genotypes had been noticed. Further, MEHP attenuated ATP manufacturing and elevated superoxide technology by each phenotypes of mouse LCs that indicated on mitochondrial dysfunction induced by the monophthalate.

All collectively, our information point out that MEHP-mediated stimulation of steroidogenesis and perturbation in mitochondrial perform usually are not related to the capability of the LCs to synthesize androgens. We recommend that this impact of MEHP noticed in LCs of rodent origin must be considered in analysis of earlier begin of puberty in boys and might spotlight a potential affect of phthalates on reproductive well being in males.

Leave a Reply

Your email address will not be published.